'Patients who were deficient in vitamin D before infection with the new coronavirus have a higher severity rate and mortality rate,' the research results show.



As various studies related to the new coronavirus infection (COVID-19) are underway, attention is focused on the relationship between the essential nutrient '

vitamin D ' and the severity of COVID-19. A new paper published by an Israeli research team showed that 'the amount of vitamin D in the body before infection has a significant effect on the severity and risk of death of COVID-19.'

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069

Vitamin D Deficiency Linked With Increased COVID-19 Severity and Mortality
https://scitechdaily.com/vitamin-d-deficiency-linked-with-increased-covid-19-severity-and-mortality/

Vitamin D Deficiency Increases Risk of Severe or Fatal COVID-19
https://www.contagionlive.com/view/vitamin-d-deficiency-increases-risk-of-severe-or-fatal-covid-19

Numerous studies have been conducted on the association between the severity of COVID-19 and vitamin D, but the results are mixed. As early as April 2020, it was reported that ' severely ill patients with COVID-19 have a high rate of vitamin D deficiency, ' and a study of 216 COVID-19 patients found that ' 80% of patients have vitamin D. It was in short supply . ' On the other hand, there is no clear evidence that vitamin D helps prevent or treat COVID-19, and overdose of vitamin D can cause health problems, as well as ' genes that affect vitamin D levels .' Based on the study, there was no association with the severity of COVID-19 . '

In January 2021, more than 200 scientists and doctors claiming that 'vitamin D intake reduces the risk of COVID-19 aggravation' issued a public letter calling for increased vitamin D intake. Did.

More than 200 scientists and doctors request to increase vitamin D intake to prevent new coronavirus --GIGAZINE



A paper published on February 3, 2022 by research teams at Bar-Ilan University and the Galaria Medical Center in Israel targeted COVID-19 patients admitted to the Galaria Medical Center with vitamin D and COVID-. The results of investigating the association with 19 severity and mortality have been reported.

In this study, 25-hydroxyvitamin D , a metabolite of vitamin D, was used as an index to measure the amount of vitamin D in the body of the subject. Of the 1176 COVID-19 patients admitted to the Galleria Medical Center from April 2020 to February 2021, blood levels of 25-hydroxyvitamin D measured 14-730 days before a positive reaction were found. A total of 253 people were documented. Of the 253 people who had data on 25-hydroxyvitamin D, 133 were diagnosed with 'vitamin D deficiency' with a blood concentration of less than 20 ng / ml, and the blood concentration was 20-. There were 36 patients with 29.9 ng / ml, 44 patients with 30-39.9 ng / ml, and 40 patients with 40 ng / ml or more.

An analysis of the amount of 25-hydroxyvitamin D in the body and the risk of COVID-19 showed that as many as 76 (57.1%) of vitamin D-deficient patients were severely or fatally ill, whereas blood levels were high. Only 4 (11.1%) patients with 20-29.9 ng / ml became severely ill or fatal, and only 4 (9.1%), 40 ng with blood levels of 30-39.9 ng / ml. Even if it was / ml or more, it was only severe and 3 people (7.5%). Even when divided into patients with vitamin D deficiency of less than 20 ng / ml and patients with vitamin D deficiency of 20 ng / ml or more, 57.1% of patients have vitamin D deficiency or more, whereas patients with 20 ng / ml or more have more than severe illness. The percentage is only 9.2%.

There was also a significant difference in in-hospital mortality between patients with vitamin D deficiency and those without. Thirty-four (25.6%) of patients with 25-hydroxyvitamin D levels <20 ng / ml died, whereas one (2.8%), 30 died of 20-29.9 ng / ml patients. There was 1 (2.3%) in patients with ~ 39.9 ng / ml and 2 (5.0%) in patients with 40 ng / ml or more, and the result was that 'the mortality rate in patients with vitamin D deficiency is overwhelmingly high'. became.



'Our findings suggest that keeping vitamin D levels normal is recommended for people infected with the virus,' said Dr. Amiel Dror of the Galaria Medical Center, who led the study. It's useful. ' Professor Michael Edelstein of Bar-Ilan University, who participated in the study, argued that the results are new evidence suggesting that vitamin D is a predictor of the clinical course and mortality of COVID-19.

in Science, Posted by log1h_ik