Thrombosis caused by some new corona vaccines may be 'caused by carrying adenovirus'

The new coronavirus infection (COVID-19) vaccine developed by AstraZeneca and Johnson & Johnson has been reported to rarely develop thrombosis after vaccination. In this case, a team of German researchers published a treatise claiming that 'the cause is the use of adenovirus as a viral vector that carries the antigen.'

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The new coronavirus vaccine uses the spike protein on the surface of the virus as an antigen . For example, Pfizer's and Moderna's mRNA vaccines are a mechanism that encloses and carries the mRNA that is the design drawing of the spike protein in a lipid capsule. Let me get it.

In contrast, the new coronavirus vaccine developed by AstraZeneca and Johnson & Johnson is a vector vaccine that uses adenovirus, which incorporates a spike protein expression gene into its DNA. Unlike the mRNA vaccine, which allows the mRNA to be read directly by

the ribosome in the cytoplasm, the adenovirus vector vaccine intentionally infects cells with adenovirus, incorporates the adenovirus DNA into the cell nucleus , and then performs gene transcription, which is a spike protein that serves as an antigen. It is a mechanism to express.

Compared to Pfizer and Moderna vaccines, which must be stored at -20 to 75 degrees Celsius, AstraZeneca and Johnson & Johnson vector vaccines are easier to store and handle at refrigerator temperatures, comparing logistics and storage costs. The big advantage was that it was low.

However, very rare cases of thrombosis have been reported with vector vaccines from AstraZeneca and Johnson & Johnson. According to a report released by the European Medicines Agency in April 2021, there were 169 cases of cerebral thrombosis out of 34 million doses of AstraZeneca vaccine in Europe. In the United Kingdom, thrombosis was reported in 309 out of 33 million AstraZeneca vaccines, and 56 deaths were reported. In addition, 28 cases of thrombosis have been reported in the United States with the Johnson & Johnson vaccine.

Regarding thrombosis, which is suspected to be a side effect of this vaccine, a research team at Johann Wolfgang Goethe University Frankfurt am Main (Goethe University) wrote in an unpeer-reviewed paper at the time of writing, 'Thrombosis after vaccination with adenovirus vector vaccine. The reason for this is likely to be the use of adenovirus as a vector. '

According to the research team, when the spike protein gene integrated into the DNA of adenovirus is expressed in cells, there is a possibility that an error will occur in gene transcription. And the team argues that error-altered peplomers can bind to endothelial cells in blood vessels, causing 'serious side effects.' Since the adenoviral vector vaccine-induced thrombosis is similar to the new coronavirus-induced thrombosis, the research team described the group of diseases caused by the adenoviral vector vaccine as ' Vaccine-Induced Covid-19 Mimicry Syndrome (VIC19M syndrome, vaccine-induced'. COVID-19 Similar Syndrome) '. In addition, the research team has rated Pfizer and Moderna RNA vaccines as 'safe products.'

Professor Rolf Marschalek of Goethe University, one of the authors of the paper, told the British economic newspaper Financial Times that 'the adenovirus vector vaccine can be redesigned' and contacted Johnson & Johnson. It is clear that it is.

in Science, Posted by log1i_yk