What are the experts' opinions on 'strange thrombosis reported after vaccination with the new corona vaccine'?
How could a COVID vaccine cause blood clots? Scientists race to investigate
https://www.nature.com/articles/d41586-021-00940-0
There have been reports of suspected side effects of AstraZeneca vaccines that 'thrombus develops after vaccination', and many countries in the EU have temporarily suspended vaccination. 'At this point, WHO believes that the benefits of AstraZeneca vaccines outweigh the risks and recommends continued vaccination,' the World Health Organization (WHO) said in a statement on March 17, 2021. He stated that he requested that he continue to use the AstraZeneca vaccine.
WHO requests countries to continue using AstraZeneca vaccine, pointing out that 'merits outweigh risks' --GIGAZINE
However, concerns about AstraZeneca's vaccine have not disappeared since then, with clinical trials in the UK under the age of 17 being suspended and Denmark saying it will stop vaccination altogether in April. Meanwhile, researchers are studying whether AstraZeneca vaccines really cause thrombosis, and if so, what is the mechanism by which blood clots develop.
After the European Medicines Agency (EMA) is a few weeks of Wataru investigation, as 'AstraZeneca made vaccine and blood clots there is likely to be related' to the April 7 announcement . In addition, the New England Journal of Medicine of the medical journal, several of which were investigated for AstraZeneca made vaccine and thrombosis research is published has been. Thrombosis suspected of being associated with AstraZeneca vaccine is a very rare case, and the EMA said in a report that 'the overall benefit of the vaccine in the prevention of COVID-19 outweighs the risk of side effects.' I am.
'Of course there is a hypothesis, whether it's a viral vector, a vaccine additive, or something in the manufacturing process ... I don't know,' said Sabine Eichinger, a hematologist at the Medical University of Vienna. ..
Eichinger said that in thrombosis that occurs after vaccination with AstraZeneca vaccine, a strange phenomenon that 'the number of platelets that coagulate blood decreases while antibodies that activate platelets are produced and blood coagulation is promoted' is seen. I noticed that blood clots appear in the brain and abdomen instead of the legs, which are generally prone to blood clots. This is similar to 'heparin-induced thrombocytopenia (HIT), ' which rarely occurs in people who receive the anticoagulant heparin.
Heparin is used to treat diseases such as thrombosis and disseminated intravascular coagulation , and is a drug that suppresses blood coagulation. HIT is a disease that causes thrombosis due to an immune response when heparin is administered, and in some cases of people who developed thrombosis after vaccination with AstraZeneca vaccine collected by EMA, heparin was administered. It seems that there was something that had the same characteristics as HIT even though it was not.
The EMA requires AstraZeneca to evaluate data from experiments and clinical trials that measure the effect of the vaccine on blood clotting to collect additional information on risk factors for thrombosis. At the time of writing, thrombosis after vaccination with AstraZeneca was reported to be more common in women than in men, especially in women under the age of 60, but the EMA concludes that women are at higher risk. not. This is because many countries have adopted a policy of 'prioritizing vaccination of health care workers', so more women than men are vaccinated with AstraZeneca. It is because it is.
To investigate thrombosis associated with vaccination, the EMA is supporting an academic consortium led by the University of Erasmus Rotterdam and the University of Utrecht in the Netherlands. The consortium's project will look for potential cases of people who have had blood clots after receiving the AstraZeneca vaccine, as well as conducting experiments to determine the dose of the vaccine and the risk of thrombosis.
The consortium's research team is also investigating whether the problems caused by the AstraZeneca vaccine are limited to some populations or have widespread effects. Eric CM van Gorp, a virologist at Erasmus Rotterdam University, said, 'What we find in Western Europe is not automatically correct in South America and other populations,' said regional differences. Pointed out that may also affect thrombosis.
And the key focus of van Gorp's research team is 'whether there really is a link between AstraZeneca vaccines and thrombosis.' With so many people already vaccinated, it can be a daunting task to determine if a suspected side effect of a vaccine was really caused by the vaccine.
Behnood Bikdeli, a cardiologist at Brigham and Women's Hospital in Boston, said, 'It's good to be vigilant about thrombosis while collecting data, but the absolute number and incidence of problem cases are surprisingly low. It's a thing. ' As the link between vaccines and thrombosis has been raised, vaccinated individuals have a higher reporting rate than unvaccinated individuals, and as a result, the overall incidence may be misunderstood. There is also.
John Kelton, a hematologist at McMaster University in Canada, has been studying HIT for 40 years. Platelet activation in HIT seems to be chained, Kelton said, 'Platelet activation is like putting a match on the crater. It mobilizes more platelets and explodes when activated. Generates blood clots. HIT is like a wildfire and is self-perpetuating. '
In the past, it has been reported that HIT develops in patients who have not been treated with heparin, although it is extremely rare, such as pathogen infection, knee surgery, and treatment with drugs similar to heparin. Kelton's team is working to identify the factors that cause HIT-like symptoms in the vaccinated body, but because of the small sample size of patients and the lack of good animal models, they will study. It seems to be difficult.
Van Gorp argues that these studies could result in more attention to the relationship between the immune system and blood clotting, which could lead to further vaccine development. 'We will soon have a new strain of coronavirus and develop a new vaccine. We need an answer for the future,' he said.
The most widely inoculated vaccines made by Physer and Moderna are 'mRNA vaccines' that use artificially replicated mRNA, but the vaccine made by AstraZeneca uses a modified virus (vector virus) that is harmless to the human body. It is a 'vector virus vaccine' that delivers the gene of the new coronavirus. Similar to the AstraZeneca vaccine, the Johnson End Johnson vaccine, which is a vector virus vaccine, has been confirmed to have thrombosis after vaccination, and US authorities have temporarily suspended the Johnson End Johnson vaccine. We advise you to stop.
Multiple reports of 'thrombosis' calling for suspension of US J & J vaccination | New Corona Vaccine (World) | NHK News
https://www3.nhk.or.jp/news/html/20210414/k10012973101000.html
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