Dec 27, 2022 15:00:00

Research results that the thrombus of the new corona vaccine is caused by 'abnormal antibodies'

AstraZeneca's new coronavirus infection vaccine has been found to ``

rarely cause rare types of thrombosis,' ' and deaths have been reported, but the WHO is of the view that ``the benefits outweigh the risks. '' are announcing. It was found that the thrombosis of this AstraZeneca vaccine is likely to be associated with a unique gene and the resulting autoantibody .

Vaccine-induced immune thrombotic thrombocytopenia is mediated by a stereotyped clonotypic antibody | Blood | American Society of Hematology
https://doi.org/10.1182/blood.2022016474

Vaccine blood clotting could be result of genetics – News
https://news.flinders.edu.au/blog/2022/04/09/vaccine-blood-clotting-could-be-result-of-genetics/

AstraZeneca vaccine: A rogue antibody and a mystery behind blood clots, study finds
https://www.smh.com.au/national/rogue-antibody-and-mystery-pathogen-behind-astrazeneca-blood-clots-study-20221223-p5c8gl.html

Studies have been conducted on thrombosis that occurs with AstraZeneca vaccines, and in May 2021, a paper was reported that ``it may be caused by using the virus as a carrier.'' rice field. This is because while Pfizer and Moderna's vaccines wrap mRNA in lipid nanoparticles and send it into the body, AstraZeneca's vaccine uses a harmless adenovirus as a vector , which causes side effects that are harmful to blood vessel cells. It is pointed out that there is a possibility that

Possibility of thrombosis caused by some new corona vaccines ``caused by making adenovirus a carrier''-GIGAZINE

Newly, a research team led by Professor Tom Gordon, an immunologist at Flinders University in Australia, published a research paper in the medical journal Blood, ``Identifying the gene that causes thrombosis caused by AstraZeneca vaccines. I did,' he reported.

According to a study by Professor Gordon and others, abnormal antibodies against `` platelet factor 4 (PF4) '', a protein involved in blood coagulation, were collected from all five people who developed thrombosis due to the AstraZeneca vaccine. . None of the five patients were related at all.

Furthermore, as a result of the research team analyzing the amino acid sequence of the antibody by a method called 'antibody proteomics ', it was found that the antibody was derived from a common basic amino acid sequence. They also confirmed that all five patients had a mutation in a gene most commonly found in people of European descent called 'IGLV3-21*02'.

PF4 is a protein involved in blood coagulation, but the 'abnormal antibody' discovered this time thoroughly attacked the PF4 protein, which rather promoted blood coagulation, and this did not result in the formation of a thrombus. The research team thinks so.

However, the results of this study still remain a mystery. In fact, 'IGLV3-21*02' itself is a gene that 4 out of 100 people have, but the risk of blood clots with AstraZeneca vaccines is much lower, so another factor may be involved. is high.

The details are unknown, but there are clues. It usually takes weeks for antibodies to develop after exposure to a new virus, but some patients with blood clots had their blood clot within days after receiving the vaccine. This suggests that patients have been exposed to adenovirus and PF4, or structures similar to these.

In Japan, booster vaccination of AstraZeneca's new corona vaccine ended in September 2022, but it is still being used in countries such as Australia.

Therefore, Professor Gordon said that he hopes that the results of this study will be useful in conducting new research on blood clots caused by vaccines and in developing therapeutic agents.