Mar 02, 2021 12:24:00

Pfizer's new corona vaccine may be less effective for obese people

A team of researchers at Istituti Fisioterapici Ospitalieri, an Italian general hospital, published a research paper showing that obese people are only about half as effective as Pfizer's new coronavirus vaccine compared to healthy people. This treatise has not yet been peer-reviewed at the time of writing, but it has been suggested that new problems related to the vaccine for the new coronavirus infection (COVID-19) may arise.

OBESITY MAY HAMPER SARS-CoV-2 VACCINE IMMUNOGENICITY --2021.02.24.21251664v1.full.pdf
(PDF file)

https://www.medrxiv.org/content/10.1101/2021.02.24.21251664v1.full.pdf

Pfizer vaccine may be less effective in people with obesity, says study | World news | The Guardian
https://www.theguardian.com/world/2021/feb/28/pfizer-vaccine-less-effective-obesity-study

Pfizer and biotechnology companies ' BioNTech ' was jointly developed ' BNT162b2 ' is messenger RNA is a vaccine that was used, and has been that there is a 90% or more of the prophylactic effect against the new coronavirus infection from the development stage. This vaccine is one of three FDA- approved vaccines and must be given twice.

At Istituti Fisioterapici Ospitalieri, 248 healthcare workers received two doses of the Pfizer vaccine, and the team investigated the antibody response seven days after the second dose. As a result, according to WHO standards, only about half the amount of antibody was detected in 'obese' people with a BMI of 30 or more compared to healthy people.

The published paper said, 'Further research is needed, but if the research is substantiated by larger data, new strategies such as giving additional vaccines to obese people will be needed. It is written.

A study by Barry Popkin and colleagues at the University of North Carolina at Chapel Hill found that obese people were 113% more likely to be hospitalized with the new coronavirus vaccine and 48% more likely to die than healthy people. Is also clear.

Studies show that obesity increases the risk of death in the new corona by 50%-GIGAZINE

Obese people may have diseases that increase the risk of worsening symptoms due to the new coronavirus, such as heart disease and type 2 diabetes , and obesity causes insulin resistance and inflammation, and the body fights infections. Make things difficult.

Symptoms such as those mentioned above can weaken the antibody response after vaccination.

A study by Scott Naditch and colleagues at Duke University shows that the flu vaccine is also less effective in obese people.

Danny Altmann of Imperial College London said, 'In countries with a lot of obesity, continuing to apply existing vaccination programs may be ineffective and it is necessary to observe antibody reactions etc. over a long period of time. '.