Research results show that the new corona vaccine can save many lives if the second vaccination is delayed and the first vaccination is prioritized.

Pfizer and Moderna's new coronavirus infection (COVID-19) vaccine is recommended to be given a second dose 3-4 weeks after the first dose. However,

in a new paper published in the British Medical Journal (BMJ) , 'delaying the second vaccination and giving a large number of the first vaccination can save many lives.' The research result was shown.

Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study | The BMJ

Delaying second Covid vaccine doses can save lives, study finds | Coronavirus | The Guardian

In principle, the COVID-19 vaccines made by Pfizer and Moderna, which are widely inoculated all over the world, are inoculated twice at regular intervals. However, the spread of the vaccine has been slow, and it takes a considerable amount of time to vaccinate all the people twice, so 'the dose of the vaccine should be halved and each person should be vaccinated once.' Isn't it? '

Vaccine developers have expressed opposition to plans to delay the second vaccination, Pfizer said on January 4, 2021 that 'the safety and efficacy of vaccines at different times of vaccination have not been verified.' Issued a statement. In addition, there is a survey result that sufficient immunity to the mutant strain cannot be obtained by only one inoculation.

However, in the UK, the policy is to approve the delay of the second vaccination from '3-4 weeks later' to 'up to 12 weeks later' in principle, and give priority to giving the first vaccination to a large number of people. I will. As a result of giving top priority to increasing 'people who have been vaccinated at least once', on April 12, 2021, the first vaccination was given to 'all people aged 50 and over and those judged to be at high risk in the country'. Has completed.

First Vaccine Offer to All UK Over 50s-BBC News

Although there were various opinions about how a single vaccination could help control infection, the Centers for Disease Control and Prevention (CDC) in March 2021 infected Pfizer and Moderna vaccines after the first vaccination. Turns out to reduce risk by 80%. British officials have also released findings that 'after a single dose of Pfizer or AstraZeneca vaccine, infections were reduced by 65% in all age groups.'

Corona vaccine reduces infection by 65% in all age groups even with a single vaccination = UK survey | Reuters

In response to this situation , even in the United States, where the government announced in January that it would not change its plan to vaccinate twice, more and more experts are thinking that 'at least one vaccination' should be prioritized. I will. Meanwhile, researchers at the Mayo Clinic , headquartered in Minnesota, USA, took the lead in presenting research results simulating the effects of changing the vaccine administration schedule and delaying the second dose.

For the Pfizer and Moderna vaccines that are widely inoculated in the United States, the research team has a standard inoculation schedule in which two inoculations are given at regular intervals, and a one-time inoculation that delays the second inoculation. Model the priority schedule. He said that he simulated how many lives would be saved by considering how effective a single vaccination would be.

As a result of the simulation, the research team found that giving priority to widespread single vaccination rather than thorough double vaccination would save more lives. According to the research team, if the effectiveness of the first vaccination is 80% and the daily vaccination rate is 0.1-0.3% of the total population, prioritizing the first vaccination will result in under 65 years of age. It has been found that the number of deaths among people in Japan will decrease by 26 to 47 per 100,000 people.

'Delaying a second vaccination will most quickly suppress COVID-19 and prevent new variants from affecting the world,' said Dr. Peter English , a public health expert. I showed it the way. ' 'We all benefit from ensuring that the whole world is vaccinated as quickly as possible,' he said, with support from countries that can afford vaccines to distribute to countries that lack vaccines. , Claimed to benefit the entire world.

in Science, Posted by log1h_ik