A new dieting approach is shown that 'limiting the intake of essential amino acids' has the effect of reducing the risk of obesity and type 2 diabetes
In general, proteins are
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution | Nature Communications
https://www.nature.com/articles/s41467-020-16568-z
Essential components of dietary restriction revealed-The University of Sydney
https://www.sydney.edu.au/news-opinion/news/2020/06/11/essential-components-of-dietary-restriction-revealed.html
Essential components of dietary restriction revealed
https://medicalxpress.com/news/2020-06-essential-components-dietary-restriction-revealed.html
Proteins, lipids, and sugars are considered as essential energy sources for human life support, and among proteins, those that humans cannot biosynthesize in the body and can only take from foods are called essential amino acids. In general, a diet that does not contain any essential amino acids is not recommended as a disease for humans, but in fact, recent studies in animals have shown that moderate essential amino acid restrictions can have health benefits. Is shown.
Restricting essential amino acids and amino acids in the diet is called 'Dietary Protein Dilution' (dietary protein dilution/DPD). From past studies on flies and mice, type 2 diabetes, fatty liver, cancer , It is considered to be beneficial in terms of prevention of elevated cholesterol levels.
Researchers at the Charles Perkins Center, an Australian medical institute, the Biomedicine Discovery Institute at Monash University, and the University of Sydney, have newly tested two young mice, threonine and tryptophan , on young and healthy mice. I was given a diet low in amino acids. As a result, it seems that mice have burned more calories than ingested calories without the side effect of muscle loss and calorie restriction. Also, mice fed a diet that reduces threonine were able to prevent obesity and type 2 diabetes.
In addition, when the research team genetically engineered mice to biosynthesize threonine that could not be produced in the body, mice did not show any effect even if they had a low-threonine diet, and they gained weight. The research team believes that the two essential amino acids are the key to a new dietary approach.
``This non-clinical trial filled one piece of a puzzle to understand the role of diet in metabolic health and longevity,'' said Steven Simpson, one of the researchers. .. Adam Rhodes, who led the research, also asked about two essential amino acids, threonine and tryptophan, 'If we could understand which dietary factors promote murine health and mimic that strategy, we could have negative side effects. The effect can be simulated without any action,” he said, calling for further research and a review of the function of the two amino acids in nutrients.
'We have seen many situations in which essential amino acids are powerful substances that influence lifelong health. Our research on these specific effects states, 'How do we use these effects for better health?' Is it possible?” said Matthew Piper, co-author of the paper.
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