The reduction of caloric intake revealed the possibility that body's oxidative stress decreases and the aging speed slows down

By refraining from daily caloric intake for 2 years, it is possible that the "systemic oxidative stress", which is said to be related to aging of the body accompanying aging, decreases and the body's aging may be delayed It is clarified by research of.

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging
https://www.sciencedirect.com/science/article/pii/S155041311830130X

Calorie restriction trial in humans suggests benefits for age-related disease | EurekAlert! Science News
https://www.eurekalert.org/pub_releases/2018-03/cp-crt031518.php

This study was conducted by a research team led by Associate Professor Lianne Redman of Louisiana State University Pennington Biomedical Research Center. "Comprehensive survey on long-term impacts due to restrictions on energy intake"CALERIEThis study, called Comprehensive Assessment of the Long-Term Effects of Reducing Intake of Energy, is the first attempt to investigate how calorie restriction affects metabolism in people who are not in obesity It is.

In the second stage survey conducted following the initial survey, 53 surveyed men and women aged 21 to 50 years with good health and not obese are under investigation. Here, the subject is divided into "a group in which the calorie from the meal is reduced by 15% over two years" and the group which sends the conventional eating habits, and it is said that it is related to the state of metabolism of the body and cell aging Changes in "oxidative stress" were investigated. In addition, at the time of the survey, in order to determine the proper amount of calories required by each individual subject more, the caloric amount necessary for maintaining the current weight is analyzed at the somatic cell level of the subject and guided from here The calorie restriction amount has been decided.


As a result of two years of calorie restriction, it has been confirmed that the subject's basal metabolic rate has decreased by 80 to 120 kcal compared to before survey. In this survey, it is said that "weight change" was not a main item, but the weight of subjects in the group who restricted the calorie at the end of the 2-year survey period resulted in an average of 9 kg It was said that it was decreasing. Although weight decreased, it seems that anemia, excessive decrease in bone mass, changes in physiological cycle and negative effects on the mental side were not confirmed. In addition, as a result of two years' calorie restriction, subjects in this group were associated with mental state and healthQuality of lifeRedman says, "Even people who are already healthy and leanly have benefited from calorie restrictions," he said.

And the most noteworthy in this study is the possibility that the risk of diabetes and cancer, etc. will decrease due to the reduction of 'oxidative stress', which is related to aging of body tissues accompanying aging It is said that there is. When the amount of calories ingested decreases, the human body acts to reduce the energy consumption by lowering the basal metabolism, so that the energy in the body will not be depleted. This work is already known and it is believed that this body's reaction is caused by "dieting restricted diet makes it less difficult to lose weight".

However, at the same time, at the same time in the body metabolic by-products "Active oxygenThe amount of generation of "decreasing" will occur. Activated oxygen damages the DNA of the body's cells, but there is a possibility that long-term body cell aging can be suppressed by decreasing this amount. "Reducing the intake of calories will lower the rate of basal metabolism of the body, limiting calorie intake, if metabolic by-products are accelerating the aging process, calorie intake restrictions over multiple years will lower the risk of chronic illness , There is a possibility of prolonging the life span. "


Although it is a research content that indicated the possibility that good health effects may exist by long-term calorie restriction, it is necessary to keep in mind that the investigation period has stayed at about 2 years. It is hoped that it will be possible to elucidate the actual situation of more accurate impact by continuing the survey. Dr. Luigi Fontana of the University of Washington, while saying "This is a very good thing" about this research, contradicts the view that Mr. Redman thinks "the decline in basic metabolism caused by calorie restriction stops aging" It shows another view that changes in the handling of nutrients by microorganisms are related.