Experts answer five questions such as 'when can a new coronavirus vaccine be made?'



The pandemic of the new coronavirus has had an impact at the industrial level, including the closure of Foxconn and Samsung's high-tech factories, and has led to a number of hoaxes and social disruption . The vaccine has not yet been developed, and the new coronavirus is increasing the number of patients and deaths, and the range of infection is expanding. Aubrey Gordon, professor, and Florian Kramer, professor of vaccination at Mount Sinai Medical School, responded.

When will there be a coronavirus vaccine? 5 questions answered

Q1: Is there a vaccine under development for coronavirus?

Several organizations, including the National Institutes of Health, have begun developing vaccines against a new coronavirus strain known as ' 2019-nCoV .' Although vaccine development has only just begun, it is believed that this vaccine development will benefit from the 2002 SARS vaccine development and the 2012 MERS vaccine development. In addition, the latest technology of ' DNA vaccine ', which creates vaccine antigens in the body, should be useful.

Q2: Did you research on specific 2019-nCoV strains?



Research has been conducted on other similar viruses that cause serious symptoms in humans, such as SARS and MERS, but the particular strain, 2019-nCoV, was not of concern to scientists. Scientists didn't even know it existed and didn't imagine it would cause human illness until the epidemic began.

Q3: How do scientists know when a coronavirus vaccine should be developed?

Serious development of vaccines for coronaviruses has been carried out since human transmission began.

However, two coronaviruses have caused serious illness in the last two decades. Given the third outbreak caused by the new coronavirus, Gordon and Kramer argue that `` we should invest in developing vaccines that can protect humans broadly against these viruses. '' I am.

Q4: What kind of development is underway and when will the vaccine actually be available?

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Vaccine development begins with identifying the appropriate target antigens and viral proteins targeted by the immune system, designing the vaccine composition, and demonstrating that it is safe and effective in animal experiments. Once animal studies have shown safety and efficacy, clinical trials will begin, with the expected immune response to humans being confirmed and safe, and then mass production of vaccines for the general public to begin.

As of January 28, 2020, there is still a shortage of coronavirus strains to sample in experiments and there is not enough antibody to confirm that the vaccine is appropriate. You need a virus to make sure that the vaccine works and elicit an immune response, and you also need to secure a mouse or nonhuman primate to do animal experiments.

As a result, vaccine development can take months.

Q5: Is there a day when we can protect humans from such disease outbreaks?

These types of epidemics are expected to occur at irregular intervals in the foreseeable future.

To avoid disease pandemics and pandemics, increase surveillance in both humans and animals around the world, and invest in risk assessments where scientists assess the potential threat of the virus to humans. Need to be able to detect.

Creating a vaccine approach that can be rapidly adopted when new viruses similar to the coronavirus, Zika, Ebola, and influenza emerge requires global action. At this time, most of the responses to new pathogens are “after-the-fact” reactions, and ongoing investment is thought to require a more “preventive” approach.

in Science, Posted by logq_fa