Researchers report that pertussis is evolving into a `` super bug '' where antibiotics do not work



Australia says that pertussis , a respiratory tract infection characterized by a condition that lasts for as long as it takes 100 days to completely cure it, is becoming a drug-resistant bacterium (superbug) that is resistant to antibiotics . A research team at the University of New South Wales revealed.

Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens-ScienceDirect

Whooping cough evolving into a superbug | UNSW Newsroom

Evidence Shows Whooping Cough Is Evolving Into a 'Superbug', Scientists Warn

Whooping cough is a respiratory infection that spreads through droplet infection, and when it starts in full swing, a convulsive cough appears repeatedly. The number of pertussis patients worldwide is about 16 million annually, of which 70% are younger than 5 years and 38% are less than 6 months old. Under 1 year mortality is about 1% to 2%, killing tens of thousands of people every year.

It has been said that such whooping cough can be prevented by inoculating the ' pertussis vaccine '. However, a research team at the University of New South Wales has shown that whooping cough is becoming resistant to a vaccine, a cell-free vaccine.

Researchers have analyzed the proteins that encapsulate Bordetella pertussis on a cell-by-cell basis and found that it produces more nutrient-binding proteins and membrane transporters than before. This change indicates a 'metabolic adaptation' of B. pertussis, which may have evolved to more efficiently deprive the host of nutrients while avoiding immune system responses. 'In simple terms, B. pertussis is evolving into a superbug, with better 'hiding' and 'securing food',' said lead author Dr. Lawrence Lou.



A superbug is 'a bacterium that does not work with antibiotics.' Humans have developed antibiotics to eliminate harmful bacteria such as pathogenic Escherichia coli from the body, but cells have evolved so that antibiotics do not work. The struggle for survival between humans and bacteria is endless.

Dr. Lou explains that the evolved B. pertussis is good at hiding, so it can be transmitted to vaccinated people. The evolved B. pertussis does not provoke an immune response, so it is said to be 'free of symptoms even if infected'. In this case, the affected person is not aware that he has “pertussis”, so the infection is easier to spread than before.

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Prof. Ruiting Lan, who led the research team, stated that 'a new vaccine effective against B. pertussis should be developed' and reiterated that 'vaccine vaccination with conventional vaccines should be continued.' 'The number of cases of whooping cough has been increasing over the past decade, but it has remained low compared to before the pertussis vaccine was introduced. To protect newborns that are not resistant to pathogens,' said Lan. High vaccination rates need to be maintained, and vaccination is especially important for those who come into contact with children and pregnant women. '

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