Research results will be announced that will greatly review the relationship between serotonin and depression

ByBoudewijn Berends

Dozens of internationally renowned researchers are involvedMeta-analysisIt is suggested that the research results of 2003, which examined mutual relationships such as serotonin gene, stress, depression, etc., were outrageous contents.

Big New Study Challenges A Genetic Link to Stress, Depression | Psych Central News
https://psychcentral.com/news/2017/04/10/genetic-link-to-stress-and-depression-questioned/118890.html


Scientists have been in the brains of stressed people for many years "SerotoninI've been studying how genes related to depression affect depression. "Selective serotonin reuptake inhibitor(SSRI) "clinically relieves the symptoms of depressed patients at a considerable rate, many scientists said that" the difference in genes affecting serotonin is related to the risk of depression and It is highly probable that it is related. " Indeed, "a prominent research paper published in 2003" states that individuals with genetic mutations are more likely to develop depression when exposed to stress in their lives.

Since many scientists have been conducting research on serotonin · gene · stress during the decades since the research in 2003, researchers at Washington University School of Medicine have investigated survey data for the past 10 years Meta-analysis, it seems that no clear association was found between the three elements of serotonin gene, depression, and stress.

ByLookcatalog

It is common for "research results may be wrong", and in fact, open access scientific journalsPLOS ONEHalf of the research published in recent years has not been reproduced or demonstrated or proved over time. Papers released in 2003, which was pointed out to be mistaken, have been quoted on research papers in the same field for over 4000 times so far, and "The serotonin gene" cited the same paper "Stress More than 100 papers have been published on such topics as "lifestyle habits" and "relevance to depression risk".

A thesis summarizing the results of this meta-analysisJournal of Molecular PsychiatryIt is open to the public. Robert C. Culverhouse, Associate Professor of Medicine and Biostatistics, led the research group, "Our goal was to gather all the data on serotonin gene and depression and review the content" We confirmed that the serotonin gene does not affect the stress change caused by depression after combining the results with the same statistical analysis of all the data. "

ByXavier Béjar

Until now, research in this field has been told that patients with genetic mutations are more likely to develop depression if they are stressed. Dr. Laura Gene Bielt, MD, MD, a medical doctor involved in a meta-analysis, said, "The idea of" becoming depressed when you receive stress "is a very reasonable hypothesis until now due to mutations in the serotonin gene" I am talking.

However, although the results of this study deny that "a specific gene is related to depression" as thought so far, "stress is related to depression" And that "Genetics is related to depression" is clear from the results of the meta-analysis.

In addition, Mr. Culverhouse and Mr. Bielt said that particular serotonin genes were excluded from potential risk factors for depression, so researchers focused on other genes and environments that could affect depression development We will be able to hit.