Researchers warned that waste of time is part of medical experiments using mice as a substitute for humans
Over the past few decadesExperimental mouseHas been used as a substitute for humans to study diseases and injuries. But,SepsisThere is a possibility that the experiment using the mouse may have derived the erroneous result, according to the New York Times.
Health Testing on Mice Is Found Misleading in Some Cases - NYTimes.com
According to the paper, although experiments with mice are not useful for studying all human diseases, it is said that diseases related to the immune system contain troublesome problems.Bulletin of National Academy of SciencesThe paper published in Mouse Experiment pointed out a case where 150 drugs for sepsis, which was developed based on mouse experiments and was invested huge cost, were useless for human beings. Although mice develop symptoms similar to human sepsis, they argue that the experimental results were inappropriate for use in drug development, as it is quite different from human. Dr. H. Shaw Warren, a researcher at the Massachusetts General Hospital who is the author of this paper, commented, "Our paper pointed out that there is a high possibility that at least parallel situations are present at the moment" It is.
Also, one of the experts who are not involved with the researchers in this thesis "In the United States, 750,000 people will suffer from sepsis each year, half of them will die, and a seventeen billion dollar budget for sepsis Although it is allocated, the situation which is the main cause of death in the intensive care room has not changed, but the research result of this thesis may have the potential to change the worldwide flow, "he says, Other experts are surprised at the content and importance of this paper.
Sepsis is a symptom that leukocytes and others cause an excessive reaction to toxic molecules, proteins released from cells damaged by trauma or burns from bacteria, viruses, fungi. According to a survey conducted by 39 research institutions nationwide over 10 years for patients who are causing such symptoms, specific genes act when white blood cells start to react too much It seems that it turned out to be. As a result, it turned out that there are some interesting patterns in relation to specific genes and leukocytes, but it was not clear in mice whether the same gene worked like a human. Based on this result, the suspicion that mouse experiments may not be able to reproduce human symptoms was born, and Ronald W. Davis, a genetic research expert at Stanford University who later was a member of the research team, I was forced to start thinking about the question "Is human being the same as mouse?"
The research team continued his research in hopes of finding similarities in the reaction between humans and mice, but eventually I could not find anything. As a result, they found that there is a case that there is no similarity between how the mouse and human genes workNatureWith magazinesScienceI sent it to a magazine, but it was never published as a paper. Both magazines announced that "We are not disclosing the reasons for not posting, and we do not publish anything about whether we actually received this paper." In fact, since the Sates magazine receives 13,000 papers annually and posts only about 7% of it, it may not be surprising that this paper was not published. However, Mr. Davis, who was a member of the research team, did not point out the scientific mistake of the peer-reviewed articles, and he said, "There is a possibility that the reason is wrong, but the reason is wrong He pointed out that he got only ambiguous comments. Another researcher said, "I was terribly surprised that the results of the mouse's research were insufficient to be so reliable when I read the paper.If you do not propose experiments with the mouse to acquire research funding It is said that it is not bad.
It is very difficult to kill mice with bacterial infections, living around the garbage and sometimes talking rotten things Mice are not the same as humans. While researchers say that if you can figure out why mice were tolerated, it might be useful for treating human diseases, while other experts say "What this paper points out is, It is the importance of gathering cells and going to the site to understand septicemia rather than a mouse rather than a mouse. "
So, it seems that mouse and human are not the same, but in addition to the circumstances that human creatures can not be done, there is no choice but to substitute for some kind of living things, perhaps because of cost There seems to be a doubt about the situation in which the mouse is treated as if it is a versatile substitute as there are problems.
in Note, Posted by darkhorse_log