Possibility to develop general-purpose therapeutic drugs by finding common genetic characteristics that cause mental illness

ByBe- Younger.com

depression(Major depressive disorder)YaschizophreniaAlthough drug therapy for mental disorders such as mental disorders has advanced significantly in recent years, no silver bullet has yet been found. However, researchers at King's College London have reported major depressive disorder / schizophrenia /Bipolar disorderBy examining the genetic characteristics of subjects suffering from three mental illnesses, we discovered factors common to the three diseases. Since common terms of genetic characteristics were found in three mental illnesses, it is pointed out that psychiatric disorders have a commonality beyond what is considered, and the possibility of curing a wide range of psychiatric diseases by finding out common factors It is.

Psychiatric genome-wide association study analyses implicit neuronal, immune and histone pathways: Nature Neuroscience: Nature Publishing Group
http://www.nature.com/neuro/journal/v18/n2/full/nn.3922.html

Psychiatric illnesses have more in common than we thought - which could be good news for treatment | The Verge
http://www.theverge.com/2015/1/19/7629169/shared-genes-mental-illness-schizophrenia-depression-bipolar-pathways

It is human genetic informationHuman genome, Attempts to explore the causes of various diseases have been continued and are utilized for the development of therapeutic drugs. As an analysis method using the human genome,Single nucleotide polymorphismFind the susceptibility gene of the disease by marking the mutation of "Genome-wide association analysis(Genome Wide AssociationStudy: GWASThere is a technique called "multiple genes", which are attracting attention as being effective in cases involving the onset of disease.


The research team of Dr. Peter Holmans et al. Of King's College London compares genetic information of subjects by GWAS with about 33,000 patients with mental illness and about 28,000 people without mental illness as subjects , We investigated whether there is a strongly relevant route to genetic mutation related to mental disorders. Then, by investigating which route commonly contributes to multiple mental diseases by ranking the contribution degree of each mental disorder to the risk of onset, major depressive disorder / schizophrenia · They discovered that there is a common route to increase the risk of developing bipolar disorder.

ByWalter A. Aue

Dr. Holmans says that "living environment" as a cause of the onset of mental illness is no doubt, while saying that "genetic factors" also greatly influence, genetic commonality which is related to multiple mental diseases I believe that further research will make it possible to develop drugs effective for many mental disorders.