Study results showing that the cause of migraine is "vascular disorder"

ByAvenue G

Migraine is one of the health problems everyone knows, and it is said that one in five people is experiencing, but the mechanism of migraine is not yet elucidated. Many physicians and scientists hypothesize that migraine is caused by vascular and neurological disorders, but supports the hypothesis about conventional migraine, "migraine comes from the problem of the blood supply system" The research result was announced at Nature Genetics.

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine: Nature Genetics: Nature Publishing Group
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3598.html


Migraines may be a vascular disorder | Ars Technica
http://arstechnica.com/science/2016/06/genes-link-migraine-to-blood-flow/

Research published at Nature Genetics combined cases of more than 35,000 migraine cases and 22 related genome-wide studiesMeta analysisWhat did you do. Through this meta-analysis, 38 independent genomic regions related to migraine were discovered. Near the discovered geneLocusAnd found that some of them are related to vascular disease. Besides, it becomes a blood vessel wallSmooth muscleShrinkage,Vascular toneMany genes that regulate arterial function associated with migraine have been found.

Because migraine often develops in conjunction with stroke and cardiovascular disease, it can be predicted that it is related to genes of cardiovascular disease, but the result of meta-analysis clearly is "vascular dysfunction and smooth muscle function It is content to support the conventional hypothesis that insufficiency causes migraine. "

ByShigemi.J

Meanwhile, migraine may accompany vomiting and diarrhea, but in this study the genes related to the bowel could not be related. The research author says "This gastrointestinal tract is made up of smooth smooth muscle tissue, so it may be possible to strengthen the research result that the smooth muscle gene causes migraine."

The fact that the majority of the 38 genomic regions were associated with blood vessels and smooth muscle cells supports the existing hypothesis that migraine is a disease associated with vital vessels in the human body. Although it is not definitive evidence, the nervous system transmitting nerve electrical pulsesIon channelAlso, an association between genes that regulate ion levels and migraine has also been found. These findings have the potential to be indicative research in investigating the relevance of migraine in the future.