It turns out that the internal organs that are considered unnecessary for human beings are greatly involved in the onset of Parkinson's disease

The " appendix " located at the end of the large intestine is not considered to be an essential essential organ in the living of modern humans, and when bacteria propagate for some reason in the appendix causing appendicitis , it becomes severe Sometimes it is resected before. The Van Andel Institute (VARI) reports the results of such research that such appendix is ​​significantly involved in the incidence of Parkinson's disease .

The vermiform appendix impacts the risk of developing Parkinson's disease | Science Translational Medicine
http://stm.sciencemag.org/content/10/465/eaar 5280

Parkinson's disease could originate in appendix, study finds | Society | The Guardian
https://www.theguardian.com/society/2018/oct/31/parkinsons-disease-could-originate-in-appendix-study-finds

Parkinson's disease is a disease in which the regulation of exercise does not go well due to dopamine which is a neurotransmitter being not secreted in the brain, disorder appears in the movement of the body. It is also known that Michael J. Fox who starred in the movie "Back to the Future" and Muhammad Ali of Prizefighter were suffering. As of 2018, no fundamental cure for Parkinson's disease has yet been found.

VARI's research team analyzed Sweden's over 1,000,000 health records and discovered that the risk of developing Parkinson's disease in people who had appendices due to appendicitis and the like was 19% lower than those who had not resected . Vivian Lovely, associate professor of VARI, who is responsible for the thesis, said, "Although appendix was said to be almost unnecessary, in fact it controls the main part of the immune system by controlling the composition of good bacteria in the intestine In our study of this time, I understood that it is also involved in Parkinson 's disease. "

It was also found that the appendix stores mutated α-synuclein protein. This α-synuclein is a protein whose function is still unknown. Abnormal α-synuclein, whose structure has been mutated due to some cause, is thought to cause neurodegenerative diseases including Parkinson's disease. Therefore, it became clear that the appendix that stores abnormal α-synuclein is closely related to the onset of Parkinson's disease.

However, this abnormal α-synuclein appears to be found also in the appendix of a person who does not develop Parkinson's disease, and only α-synuclein does not cause Parkinson's disease, it is only one of a plurality of etiologies The research team argues that there is.

Assistant Professor Lovely commented that "appendectomy only reduces the risk of developing Parkinson's disease, not a complete prophylaxis." "This is valuable epidemiological evidence that has relevance to intestinal pathology and the risk of developing Parkinson's disease, which is an abnormal appendix," said Tom Fortiny, a neuroscience laboratory at University College London . "Why is storage of α-synuclein easier to develop Parkinson's disease, and why people who do not develop resistance are resistant to future research".