By simply changing the new corona vaccine from intramuscular injection to subcutaneous injection, it may be possible to reduce side reactions while maintaining the effect.
It is important that as many people as possible receive the COVID-19 vaccine to avoid the spread of the new coronavirus infection (COVID-19) and bed pressure. However, since many people have side reactions such as pain, fever, fatigue, and joint pain at the inoculation site with the COVID-19 vaccine, I think that I do not want to receive the third vaccination (booster vaccination) because the side reactions are difficult. There are also people. Meanwhile, a research team at the
Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes | PLOS Biology
https://doi.org/10.1371/journal.pbio.3001643
Changing the way we jab might help stop post-vax fatigue --Scimex
https://www.scimex.org/newsfeed/changing-the-way-we-jab-might-help-stop-post-vax-fatigue
A Tiny Change in Jab Strategy Might Reduce COVID-19 Vaccine Fatigue, Mouse Study Finds
https://www.sciencealert.com/different-technique-could-reduce-covid-19-vaccine-fatigue-mouse-study-suggests
Adverse reactions after COVID-19 vaccination are factors that make people hesitate to vaccinate, and at the time of writing the article, 80% of the total population completed two vaccinations in Japan, while booster vaccination . Only a little less than 60% of people have completed the procedure . In fact, many experiences that 'the third side reaction is painful' have been reported on the Internet and SNS, and it is thought that methods to reduce the side reaction will help improve the inoculation rate.
There, a research team led by Eng Eong Ooi , a virology professor at Duke-NUS Medical School, analyzed blood samples from 175 healthcare workers vaccinated with the Pfizer vaccine. This revealed that people who experienced moderate to severe side reactions after vaccination expressed more genes related to the activation of T cells and natural killer T cells , which are the major cells in the immune system. That thing. A strong immune response means that the inflammatory response after vaccination is strong and the side reactions are heavy.
The research team then conducted an experiment with mice to investigate 'whether the severity of adverse reactions changes depending on the vaccination method.' Most vaccines, including the COVID-19 vaccine, employ an intramuscular injection that injects the vaccine into the muscle tissue behind the subcutaneous fat. This is because many immune cells that recognize pathogens are present in muscle tissue, and there are also abundant blood vessels that help transport substances. Immune cells in the muscle can quickly take up the antigen in the vaccine and deliver it to the nearest lymph node (armpit if inoculated on the shoulder).
On the other hand, since there are few immune cells and blood vessels in the subcutaneous fat layer, the immune cells cannot take up the antigen quickly by subcutaneous injection, and the supply to the lymph nodes is delayed, so the effect of vaccination is compared with that of intramuscular injection. And is considered weak. Studies have shown that subcutaneous injections with vaccines such as hepatitis B and rabies do not provide sufficient results .
The research team divided the mice into a 'Pfizer vaccine intramuscular injection group' and a 'Pfizer vaccine subcutaneous injection group', and analyzed the immune response after inoculation and the protective effect from COVID-19, respectively.
As a result, it was confirmed that the mice that received subcutaneous inoculation had the same or better protective effect as the mice that received intramuscular injection, and that the expression of genes showing an inflammatory reaction was low. In other words, switching the COVID-19 vaccine from intramuscular injection to subcutaneous injection may reduce side reactions while maintaining the vaccine's effectiveness.
'This study provides the first insight into the molecular basis of the side reactions that many have experienced after mRNA vaccination. The mechanism by which this finding supports the side reactions associated with vaccination,' said Ooi. We look forward to further research to understand and contribute to the development of more
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