Should I be vaccinated even if I am infected with the new corona?



As a way to immunize against the new coronavirus infection (COVID-19), it is sometimes said that it is better to be infected with COVID-19 than to be vaccinated. In fact, it is How can obtain the immunity by infecting COVID-19, but still it's important to hit the vaccine

micro-biology , a researcher of Beth Marie Mole Mr. has explains.

No, your antibodies are not better than vaccination: An explainer | Ars Technica
https://arstechnica.com/science/2021/10/prior-infection-vs-vaccination-why-everyone-should-get-a-covid-19-shot/

◆ Vaccine efficacy may be underestimated



The effectiveness of the vaccine is basically evaluated by comparing 'people who have been vaccinated' with 'people who have not been vaccinated'. It should be noted here that in the case of the United States, 'people who have not been vaccinated' include 'people who have already had some immunity due to being infected with COVID-19 in the past'. .. People with immunity are less likely to be infected with COVID-19, but they are not considered during the course of the study, resulting in a low evaluation of the vaccine's effectiveness.

Considering the above, the COVID-19 vaccine is highly effective, with the

Pfizer / Biotech vaccine having a 90% efficacy lasting for at least 6 months and the Moderna vaccine having a 93% efficacy. It has been confirmed.

In addition, the immune response obtained by infection varies depending on the severity of the symptoms, and there is a big difference that the immune response is weak in those who have mild symptoms and the response is strong in those who have severe symptoms. I already know. A study published in June 2020 reported that those who recovered from COVID-19 had high levels of neutralizing antibodies , a 40,000-fold difference, and those who had detectable neutralizing antibody levels. Was about 20% at most. From this, it is considered that the immunity obtained by infection is inferior to that of vaccines in terms of certainty and reliability.

◆ Differences in antibodies



Antibodies are not the whole immune response, but a

study of 12,500 health care workers published in December 2020 showed that higher antibody levels reduced the risk of infection. It was also announced in May 2021 that there was a 'very strong relationship' between neutralizing antibody levels and vaccine protection.

Infection immunity targets all aspects of the new coronavirus (SARS-CoV-2). On the other hand, the COVID-19 vaccine targets the spike protein of the virus, so there is a difference that 'infection-induced immune antibodies are diverse, and vaccine-induced antibodies are not.' Conversely, vaccines have 'highly targeted antibodies.'

◆ Impact of Delta stock



In June 2021, a study was announced stating that 'people infected with SARS-CoV-2 are less likely to benefit from COVID-19 vaccination.' On the other hand, a study published in August 2021 concluded that 'people with a history of infection and unvaccinated are 2.34 times more likely to be re-infected than those with a history of infection and vaccinated.' I did. These differences in research results are thought to be influenced by the Delta strain.

Studies conducted during the Delta epidemic have also shown that neutralizing antibody levels to the Delta strain are 4-6 times lower than those of the pre-Delta mutant.

A study published in Nature in July surveyed 47 people one year after SARS-CoV-2 infection. Twenty-six of the subjects were unvaccinated and 21 were vaccinated once, while the unvaccinated group had very low levels of neutralizing antibodies to the Delta strain, 'mostly detectable neutralizing antibodies. I don't have a level. ' In contrast, the single-vaccinated group was noted to have neutralizing antibody levels equal to or higher than those who received two vaccinations.

As mentioned above, vaccination is important because there are three factors: 'there is a large difference in the immune response due to infection', 'the neutralizing antibody level is lowered by the Delta strain', and 'the vaccine is very effective'. Mole concluded.

in Science, Posted by logq_fa