Research results show that among those vaccinated with the new corona, 'experienced infections' have 56% higher antibody titers 6 months after the second vaccination.



A study of about 2000 follow-ups of healthcare workers over a 6-month study found that among those vaccinated against the new coronavirus infection (COVID-19), 'experienced' were 6 months after the second vaccination. A research team at John's Hopkins University in the United States announced that the antibody titer will increase by 56% at that time.

Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection | Infectious Diseases | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2785919

In COVID-19 Vaccinated People, Those with Prior Infection Likely to Have More Antibodies
https://www.hopkinsmedicine.org/news/newsroom/news-releases/in-covid-19-vaccinated-people-those-with-prior-infection-likely-to-have-more-antibodies

Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern | Nature Microbiology
https://www.nature.com/articles/s41564-021-00974-0

Post-Infection COVID-19 Antibodies Last at Least 10 Months, New Evidence Suggests
https://www.sciencealert.com/covid-19-antibodies-last-at-least-10-months-in-infected-people-evidence-suggests

A paper published by Diana John and colleagues at Johns Hopkins University on November 1, 2021 found that 1960 healthcare workers were tested for COVID-19 antibody titers one month after the second vaccination.・ Measured after 3 months and 6 months. Of the 1960 subjects surveyed, 73 had been infected with COVID-19, 41 of whom were infected within 90 days of the first vaccination and 32 of whom were infected before 90 days. ..

Each subject received a total of two doses of either the Pfizer vaccine or the Moderna vaccine, and the antibody titer of COVID-19 was examined 1 month, 3 months, and 6 months after the second dose. .. As a result, it was found that there is a difference in antibody titer of 14% 1 month after vaccination, 19% 3 months after vaccination, and 56% 6 months after vaccination between those who have experienced infection and those who have not. Did.

In addition, the results show that 'the antibody titer is higher when the interval from infection to vaccination is increased'. A comparison of 41 individuals infected within 90 days of the first vaccination with 32 individuals infected before 90 days showed that the antibody titers of subjects infected before 90 days of the first vaccination were the second inoculation. It was 9% higher one month later and 13% higher three months later.



In addition, a study published by Lian Dupont and colleagues at King's College London in the United Kingdom, published on October 15, 2021, showed that COVID-19 antibody after infection lasts for at least 10 months. increase. When DuPont et al. Followed up the antibody titer of COVID-19 in 38 subjects in the recovery phase after infection, it was found that the antibody continued to be detected even 10 months after the end of the survey. ..

In addition, the infected subjects who were the subjects in this survey were infected with SARS-CoV-2, which is the original species, but the antibodies produced were B.1.1.7 (alpha strain) and P.1 (alpha strain), which are mutant strains. It was also confirmed that it showed a certain degree of effectiveness against Gamma strain) and B.1.351 (Beta strain).

'Our findings and other recent studies show that antibody titers decline from the early stages of infection, but strong neutralizing activity against both pseudotyped and infectious viruses is present even 10 months after onset,' said Dupont. It has been shown to be detected in most of the cases. '

in Science, Posted by log1k_iy