The 'real effect' of exercise on metabolism is found, but some people can not enjoy the benefits of exercise



The view that 'exercise is good for the body' agrees with many, but new research has made it clearer how exercise affects metabolism. Researchers investigated the effect of metabolism on an 80-day exercise program using 'recruiters' who had almost the same sleep time, diet, and lifestyle.

Effect of chronic exercise in healthy young male adults: a metabolomic analysis | Cardiovascular Research | Oxford Academic

https://academic.oup.com/cardiovascres/article/doi/10.1093/cvr/cvaa051/5813974

Study: The “true magnitude” of how exercise influences metabolism
https://www.inverse.com/mind-body/exercise-profoundly-impacts-metabolism-study

A 2019 study conducted in the United States showed the shocking fact that only 20% of the 20s with ideal blood sugar, blood pressure, cholesterol, and no drug prescribed are in the total . Many studies published so far have shown that exercise has a positive effect on the body, but many people do not have an image of how much it will affect. John F. O'Sullivan and colleagues at the University of Sydney have shown specific results of the effects of exercise on the body's metabolism in an experiment with 52 healthy adult men.

This study is unique in its subject. The 52 subjects were US recruits with a healthy Body Mass Index (BMI) around age 26. Since the army was provided with the same food and had the same sleep pattern and daily behavior, it was possible to control potential confounding factors and clarify only the effect of exercise.

The recruits conducted aerobic exercise and strength training in an 80-day program. The subjects averaged 1.3 hours of activity per day, with 68% of the activity being moderate intensity training and 32% being high intensity training. Blood samples were taken from subjects before and after the program to examine the metabolic changes that exercise had.



Metabolism is a chemical reaction that causes the body to turn food and drink into energy, which produces by-products called '

metabolites .' Researchers investigated the true effects of exercise on the body by examining changes in 201 identified metabolites from the subject's blood.

According to the researchers, many changes were observed in the metabolites produced in the subject's body after the program was completed. For example, changes such as increase of metabolites such as arginine and ornithine to fight inflammation, improvement of immune function and increase of blood flow are mentioned.

There were also positive changes in blood clots and protein degradation, blood vessel dilation, stress reduction, and lipid, ketone and nucleotide levels. In addition, plasma fatty acids and intermediate metabolites of ketone bodies have been reduced from the blood, indicating that post-programmed subjects were liable to burn fat and ketone bodies as energy in their muscles. .

'Chronic exercise dramatically improved overall metabolism,' said O'Sullivan, who said metabolic changes could lead to fat accumulation, inflammation, and reduced stress.

Interestingly, not all participants showed such changes. Subjects with high levels of 'Dimethylguanidinovalerate' (DMGV), which have been shown in recent studies to predict a lack of metabolic response to exercise, have been shown to have no metabolic benefit through exercise. It is known that DMGV levels are affected by genes and diet, and that drinks high in sugar increase DMGV and vegetables decrease DMGV.



On the other hand, low DMGV levels in young, healthy men may indicate metabolic dysfunction, necessitating non-exercise strategies to reduce cardiovascular risk.

Since this study was limited to male subjects and people of very similar nature, it is unknown whether similar conclusions can be reached in a more diverse group, but Mr. O'Sullivan We believe this study has clarified the role of exercise in preventing cardiovascular disease.

in Science, Posted by darkhorse_log