A study result that 'baldness prevention' becomes possible appearance, let the hair follicle smell the synthetic sandalwood

by Merlijn Hoek

In the hair follicle that wraps around the hair root, there is an olfactory receptor that captures the molecule of the odor, and the research indicated that baldness can be prevented by bending a specific odor over the hair follicle.

Hope for baldness cure as scientists trigger hair growth with chemical used in perfumes: 'A rather amazing finding' | The Independent
https://www.independent.co.uk/news/health/baldness-cure-hair-loss-treatment-sandalwood-perfume-sandalore-smell-a8543391.html

Hair Follicles Can 'Smell' Sandalwood, And It Could Be a Radical New Way to Treat Baldness
https://www.sciencealert.com/hair-follicles-can-smell-things-radical-new-way-treat-baldness-odorants-olfactory-receptors-or2at4

Feeling "a good smell" or "smell" is because the olfactory receptor captures the molecule "odorous substance" contained in the air and sends a signal to activate the brain. There are many people who think of smoking air from the nose by listening to the act of "smelling the smell", but it is not only the nose that does this kind of work.

The research team of Ralf Paus et al., A dermatologist at the University of Manchester also announced that human hair follicles also exposed the olfactory receptor "OR 2 AT 4". OR 2 AT 4 reacts to specific molecules like synthetic sandalwood, it stimulates hair growth. In other words, "the hair follicle can smell the smell and prevent hair loss by separating the right molecules".

by Oleg Magni

"This is an amazing thing," Paus says, "Human common small organs can be controlled with odorous substances that are simple and cosmetically used," he says.

It has been known in previous studies that OR2AT4 promotes the proliferation and proliferation of keratinocytes present in the epidermis of humans and is useful in the treatment of wounds. Therefore, Mr. Paus said that "I think that OR 2 AT 4 will boost hair growth" and started research.

The researcher first took a sample from the scalp of a person donated by a face lift surgery and combined the sample with a synthetic sandalwood odorant like Sandalore in the laboratory.

Then, it turned out that molecules of odorous substance of synthetic sandalwood bind with OR2AT4 and control the expression and secretion of substance "IGF-1" which is the key to growth of hair. Experiments were conducted not only with synthetic sandalwood but also with genuine sandalwood odorous substances, but similar reactions were not seen in real sandalwood.

by Jayesh Patil

Later, when researchers mixed chemicals called "Phenirat", it was confirmed that OR 2 AT 4 interferes with hair growth. From this, it was shown that OR 2 AT 4 has been involved in hair growth much more than it had been thought up to now.

This research was carried out by a pharmaceutical company dealing with products containing synthetic sandalwood. Upon completion of a small experiment on 20 women at the time of article creation, on the basis of existing products, research is more focused on "prevention of baldness" rather than "bald treatment" It seems to be.

by Carolina Heza