Alcohol proved to cause irreversible damage to stem cell DNA


Even the "proper amount of sake" speeds down the cognitive function of the brainThe results of the survey will be announced in 2017 and the influence of drinking on the body has gradually become clear. The latest study published in Nature shows evidence that drinking irreversibly damages DNA of stem cells and thus causes cancer.

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells | Nature

Alcohol can cause irreversible genetic damage to stem cells, says study | Science | The Guardian

A new research published in NatureAcetaldehydeFocusing on. Previous studies have shown that acetaldehyde binds to DNA and proteinsAdductAnd those involved in various diseasesIt is considered. However, in past studies, experiments were conducted on high concentrations of acetaldehyde in laboratories and petri dishes, not actually tracking the effects in the human body. On the other hand, this research is conducted on genetically modified mice.

There are two defense mechanisms in the human body, a defense layer to remove acetaldehyde and a mechanism to remove DNA damage, but according to the contents shown in this study, the toxicity of acetaldehyde is neutralized by these two mechanisms It is said that DNA carries irreversible damage when it can not.

Especially"Aldehyde dehydrogenase(ALDH 2)It was also found that mice with no first defense layer called DNA increased damage. In humans, 8% of the world's population is genetically weak ALDH 2, and as many of these people make East Asia roots, it is said that China has a large number of esophageal cancer patients.


In this research, experiments were conducted focusing on the stem cells in the blood, but researchers think that the same effect should be seen for other similar stem cells.

And when not having both defense mechanisms, it seems that mice given alcohol diluted for 10 days have completely lost their ability to produce blood. The stem cell genomeDNA sequencingI heard that mouse cells are no longer functioning.

I did a researchMRC Molecular Biology LaboratoryProfessor Ketan Patel of Professor Ketan Patel said, "There is controversy on how much damage alcohol will deal with us," while saying, "This article shows that alcohol metabolites damage DNA of important stem cells to make body tissues It was a great proof that it gives us a feeling. "

"Our research highlighted that the risk of DNA damage is increased when alcohol can not be efficiently processed and hence the risk of certain cancers is also enhanced." But remember, Alcohol removal and DNA repair systems are not complete, it is possible that alcohol can cause cancer in other ways, even those who do not have problems with defense systems, "Professor Patel said.

bySamuel Zeller

However, it is said that drinking alcohol increases the risk of esophageal cancer, breast cancer, and colon cancer, but no evidence of raising the risk of blood cancer such as leukemia has been found. Following this research, the research team will continue to investigate why drinking is related to "specific" cancer.

in Science, Posted by darkhorse_log