Dental caries treatment may change dramatically, succeed in regenerating teeth with Alzheimer's remedy

ByEvan Long

When you cut a tooth for the treatment of a decayed tooth, usually you will put an artificial filler so it will not be completely regenerated. However, according to the information released by researchers at King's College London, he succeeded in using Alzheimer's remedy to regenerate the tooth that was damaged by tooth decay.

Promotion of natural tooth repair by small molecule GSK 3 antagonists: Scientific Reports
http://www.nature.com/articles/srep39654

Decline of the dentist's drill? Drug helps rotten teeth regenerate, trial shows | Science | The Guardian
https://www.theguardian.com/science/2017/jan/09/decline-of-the-dentists-drill-drug-helps-rotten-teeth-regenerate-trial-shows


A Drug Meant for Alzheimer's Treatment Regrows Human Teeth | Motherboard
http://motherboard.vice.com/read/an-alzheimers-drug-could-help-grow-teeth-and-fight-cavities

At first glance "teeth" looks like a mass of mineral matter, but in fact it has its own physiological function. Be under the hard enamel on the surfaceDentineThe part which is softer than enamel and has strong nature of impact, occupies most of the dental tissue. Dentin is difficult to regenerate completely once it is scraped off, so it is common to treat the tooth with padding on the cut part and cover on it. However, the cement filling used in current treatments is considered to weaken the teeth, basically it is preferable to maintain the original dentin.

Therefore, the researchers have noticed that they are used in the treatment of Alzheimer'sTideglusibA medicine called. Tideglusib has the side effect that "teeth grow", and researchers can regenerate dentin using Tideglusib? That's why I thought. In Alzheimer's treatment, Tideglusib is thought to work on abnormal tau protein that causes Alzheimer's type dementia. On the other hand, Tideglusib in the treatment of teeth acts on the stem cells in the center of the tooth, and it triggers the growth of odontoblasts.

The experiments conducted this time are targeted at mice. When I got a sponge filled with medicine on the tooth of the mouse with the defect, I heard that the teeth regeneration was confirmed. Using a biodegradable sponge and confirming the mouse's teeth several weeks later, the sponge was almost broken down and replaced with a new tooth. If this treatment method is applied also to humans, it is considered that it is possible to regain healthy teeth without artificial stuffing weakening the teeth and increasing the risk of tooth decay in the future I will.

To apply this technology to human beings, the research team is currently conducting experiments on rats with tooth holes 4 times larger than the mouse. If the experiment is successful, a clinical trial will be held for humans within 2017. However, since this method does not eliminate the task of "scraping teeth with a drill" in caries treatment, it does not mean that the fear of caries treatment will not completely disappear.