Gene recombination mosquito problem to eradicate malaria of "mosquito" killing the most human beings in history Historical movie

As many as 200 million people a year through mosquitoesmalariaIt is infected with 500 thousand people lost each year. Resistant to malaria by genetic engineering "Genetically modified mosquito"Has already been created and technologies to inherit artificial genes reliably have also been established, but once implemented, changes are made so naturally that it can not be restored, so from now on it is still in practical use I have not arrived. A movie that can understand details of such a genetically modified mosquito with an illustration & Japanese translation has been published.

How To Eradicate One Of Our Deadliest Enemies - Gene Drive & Malaria - YouTube


What if genetic engineering could beat the most dangerous monster?


A horrible monster killing the human being most in history is known as "mosquito".


Mosquitoes are dengue, jika fever, yellow fever and ...


It mediates malaria.


Malaria is said to be the worst killer in history ... ...


By 2015 alone, there are 200 million people infected, of which 500,000 have died.


Such malaria may be eradicated with new technology.


That technology is a gene recombination technology that will rebuild the whole organism ... ...


"Genetically modified mosquito" already resistant to malaria has been completed.


Whether or not to actually release this "genetically modified mosquito" into nature is debated.


Malaria isMalaria parasiteEukaryotic organisms consisting of just one cell are infected by migrating to vertebrates through blood-sucking insects.


The malaria parasite hides in the mosquito and aims at the moment of blood sucking.


Malaria that has invaded the human body from mosquito saliva heads to the liver and is hidden within the cell so as not to be attacked by the immune system.


Malaria that grew over the course of a month in the liver turned into a form called "merozoite" ... ...


Eventually, cells in the liver will jump out and spread to the whole body.


I target red blood cells while moving on the bloodstream, but malaria can hunt the immune system by covering the skin of the destroyed cell.


It is like a zombie that wears the killed partner 's skin.


It enters the erythrocytes and proliferates and attacks the next erythrocyte. I repeat the action ....


Because broken cells release toxic substances, they cause a strong immune reaction.


The immune reaction causes the human body to have high fever, perspiration, cold, headaches and ...


It appears as symptoms such as muscle pain / vomiting / diarrhea.


When it infects the brain, it becomes a coma, and in the worst case it dies.


Furthermore, it can move to a new target by passing through the mosquito that sucked the blood of the infected person, and has a cycle of going back and forth between mosquitoes and humans.


Although the distribution of Jika fever causing microcephaly spreads in 2015 ... ...


This is also caused by mosquitoes.


Mosquitoes are carriers of excellent diseases and exist on Earth over 200 million years ago.


A few trillion people live on the earth, one grows 300 eggs at a time and it breeds tremendously, so call it "parasite taxi" which is impossible to extinct I can.


What can be expected as a countermeasure against such mosquitoes is "CRISPR(Crisper)A new technology called 'The Society'.


With unprecedented genetic recombination technology that can change one species entirely, it can have resistance to specific hereditary factors.


If you use Crispa you can change the nature of the mosquito, not mosquitoes ... ...


It is an attempt to create a harmless mosquito that does not mediate disease even if it is stabied by adding genetic antibody specialized in malaria to mosquito gene.


However, it is not sufficient to just create a "genetically modified mosquito". Because there are two types of genes, because it is half of descendants inheriting artificial antibodies ... ...


Mosquitoes with antibodies will eventually become a minority even if they release in nature.


The method established to solve this problem is "Gene drive"Genetic manipulation technique called.


It succeeded in inheriting the character of detoxifying malaria to 99.5% of the descendants of "genetically modified mosquitoes" in order to surely inherit specific genes to the next generation.


If you release mosquitoes that have genetically edited in this way to nature, you can rapidly spread mosquito genes that are resistant to malaria.


As genes remain permanently, malaria can not live in mosquitoes.


Moreover, by rapidly changing the environment, it is expected to be settled before malaria with resistance emerges.


Since there are 500,000 children dead each year in malaria, five people have already died since the movie started. Some also argue that this technology should be used immediately.


Mosquitoes, parasites and viruses are not in a symbiotic relationship, and even if malaria is eradicated it will not cause problems in mosquito life.


If this is successful, there are other mosquito-mediated dengue fever, jika fever, miteLyme disease, Of a flyAfrican sleeping sickness, FleaPlagueYou will be able to cope.


It is a technology that can save lives of many people at the same time, but because it is a new technology just developed, it has not been put to practical use from various concerns. One of my concerns is that human beings never naturally added such a large scale change naturally and once it is executed it can not be restored.


There is no unprecedented possibility of a bad result being zero, it may lead to an unpredictable and terrible situation.


In the case of malaria, because there is no remodeling of mosquito shape, there is also a voice saying "There is no problem" ....


If it fails it means that mosquitoes that genetically edited inadvertently breed and malaria can not be eradicated, and the end of discussion is still not seen.


Because it is a powerful technique, it is certainly necessary to have a careful discussion, but the decision to "do not use technology" means "to abandon 1000 children dying every day."


For this reason public discussion is required for this issue, and in any case it is imperative to make decisions within a few years.