The era will come soon "Intestinal bacteria will cure your disease"

ByDay Donaldson

About 10 trillion to 1000 trillion microbes in the human intestine,Intestinal bacteria(Intestinal bacteria) exist. Research is in progress to cure human diseases using this intestinal bacterium, and soon there will be the first therapeutic drug using intestinal bacteria.

Coming Soon: Gut Bacteria That Actually Cure Your Disease - Bloomberg
http://www.bloomberg.com/news/articles/2016-06-30/coming-soon-gut-bacteria-that-actually-cure-your-disease


Everyone has bacteria in the intestines, but there are researches that this intestinal bacteria is effective in treating cancer and prevention of depression. However, at the present time there is not much evidence that intestinal bacteria work well for the human body. "Intestinal bacteria are promising, but there is currently little evidence to support this," he says,America Disease Control CenterMr. Cliff McDonald, deputy director of health care promotion department of CDC.

According to BCC ResearchReportSo, in 2015ProbioticsIt is estimated that the market will be 34 billion dollars (about 3.5 trillion yen). And, among them, the market for luxury goods related to probiotics is estimated to be as high as $ 24.8 billion (about 2.5 trillion yen).

Aim for success in the probiotic marketSeres TherapeuticsIs a company that sells biopharmaceuticals based on the microorganism group "microbiome" present in the human intestine. Based on the approval review of the US Food and Drug Administration (FDA), Seres causes intestinal diseases such as diarrheaClostridium difficileWe are developing tablets to treat. CDC estimated that as many as 500,000 people are infected with Clostridium difficile every year, of which 29,000 have died. Seres Therapeutics is trying to make a tablet that can treat Clostridium difficile based on the research result that "When 93% of diarrhea is cured when we transplant feces other than ourselves into the intestine," Seres Therapeutics clarified in 2016. These supplements related to probiotics are all products related to intestinal bacteria.

It is confirmed that 93% of diarrhea will be cured when transplanting feces other than yourself into the intestine - GIGAZINE


Besides, SeresobesityAnd liver disease,gunResearch is also being done to treat bacteria with intestinal bacteria. These studies are conducted in cooperation with the Massachusetts General Hospital, Mayo Clinic, Memorial Sloan Kettering Cancer Center, and other medical institutions. "We are aiming to accurately understand the workings of micro-biomes, design drugs, treat disease without touching human beings," said Seres's CEO Roger Pomeranz.

The tablet developed by Seres is called "SER-109" and if you drink 4 tablets, you can treat Clostridium difficile without transplanting feces into the intestine. The material of this tablet was extracted from fecessporeIt seems that they are sterilized into tablets.

If "SER-109" is marketed, it will be the first tablet for microbeam treatment obtained approval from FDA. However, Seres avoids comments on the specific time when "SER-109" is marketed. In addition, Seres also develops therapeutic drugs other than "SER-109" such as "SER-287" to treat ulcerative colitis. Even companies other than Seres seem to be conducting research to obtain approval from the FDA, but at the present time Seres is missing one in the development of therapeutic drugs using intestinal bacteria about.

"Seres will probably be the first company to knock on the door of the FDA," as with Seres, will develop therapeutics that make use of intestinal bacteriaSecond GenomeMr. Mohan Ayal. "SER-109 is ready to be the first medicine to transplant bacteria into the body,Leerink PartnersMr. Joseph Schwartz, an analyst.

Besides, Seres is a competitorRebiotixI am developing a tablet called RBX 2660. Like SER-109, it is intended to treat Clostridium difficile, but unlike SER-109, it is taken into the body with an enema. Of course, Rebiotix is ​​also developing the same oral version of RBX 2660 as SER - 109.