At last the Viagra appearance for women? The effect of raising female libido in drugs developed as antidepressants

Originally as an antidepressantBoehringer IngelheimDeveloped byFlibanserin(Flibanserin)A drug called women'sHypoactive Sexual Desire Disorder(HSDD: impaired sexual desire)It is proved by clinical trials that it is effective for treating. The most common sexual dysfunction for men isEDOn the contrary, since libido is most common for women, flibanserin can be like Viagra for women.

Details are as below.Viagra for women? Drug developed as antidepressant effective in treating low libido

The effect of flibanserin was demonstrated by three separate clinical trials.University of North Carolina at Chapel HillAccording to Doctor of Obstetrics and Gynecology at the School of Medicine John M. Thorp Jr. Medical Doctor, these experiments are the first to test a therapy that encourages HSDD women's sexual desire at the brain level.

"Flibanserin was poor as an antidepressant," Professor Thorp. "However, aggressive researchers observed increased libido in laboratory animals and humans, so we conducted multiple clinical trials and noticeable from female subjects using flibanserin for the treatment of HSDD Promotion of libido and satisfactory sexual experiences were reported "

"Basically it's like Viagra for women.The decline in libido is the most common gender trouble for women as it is for men," Thorp says.

According to previous studies, it is known that 9-26% of women in the United States (depending on age and menopause) are HSDD. Flibanserin is currently a drug under study and can only be used by women participating in the trial.

The result of this research was the first researcher at the European Medical Society held in Lyon, France on November 16University of OttawaProfessor Elaine E. Jolly medical doctor of medicine.

Professor Jolly, Professor Thorp and others analyzed integrated data of flibanserin clinical trials conducted in the United States, Canada, Europe. In total 1946 people over 18 years old and premenopausal women over 24 weeks with flibanserin orplaceboWas given. Whether to receive Flibanserin or Placebo was chosen randomly and an observation period of 4 weeks was placed before and after the 24 week treatment period.

At the beginning of the trial, four dosing regimens were taken: 25 mg twice daily, 50 mg once daily before bedtime, 50 mg twice daily, 100 mg once daily before going to bed. However, no effects were observed when the total dose per day was 50 mg, so it was effective only in the case of a total of 100 mg, so it seems that only the administration regimen that totaled 100 mg was adopted in the second and subsequent experiments. Therefore, only three data except the first one of the four clinical trials were adopted for this survey.

The subjects' women are asked the number of times "satisfying sexual events (SSE): satisfied sexual experiences" every week for 34 weeks, "electronic diary (eDiary) desire score: eDiary's libido score", "female sexual function indexFSFI), "FSFI total score", "female sexual distress scale-revised (FSDS-R:Revised editionFSDS) And the sixth element of "FSDS-R 13 th item (items focusing on sexual desire in particular)" and analyzed the change from the 4 weeks before the baseline start of administration.

The researchers reported that 100 mg of flibanserin administered once a day before going to bed was the most effective, and the number of satisfied sexual experiences · sexual desire (measured by eDiary and FSFI score of sexual desire division) · suffering due to sexual dysfunction (FSDS - R and its item 13) · Significantly significant improvement was seen in the sexual function itself (measured by FSFI) compared with the group given placebo.

"These results will lead to a new approach to pharmacological treatment of sexual dysfunction most afflicating women at reproductive age, now it is the only cureAndrogen replacement therapyIt may lead to a therapy with no side effects in place of male hormone replacement therapy, "Professor Thorp says.