A paper is published that overturns the common sense that ``a sudden increase in insulin after a meal is bad'', research results show that people with a high insulin response have a low risk of diabetes.
When blood sugar levels rise after a meal,
Future cardiometabolic implications of insulin hypersecretion in response to oral glucose: a prospective cohort study - eClinicalMedicine
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00540-0/fulltext
Post-meal insulin surge not a villain, says new research - Sinai Health
https://www.sinaihealth.ca/news/post-meal-insulin-surge-not-a-villain-says-new-research/
“In the clinic, I often see patients who believe something they read on the internet or in a book that ``you shouldn't raise your insulin levels too high.'' Some doctors also recommend limiting postprandial insulin fluctuations. 'Some people recommend it to their patients, but the way insulin works is not that simple,' says Ravi Retnakaran, a clinical scientist at the Lunenfeld-Tannenbaum Research Institute (LTRI) in Canada.
The human body has a mechanism to keep blood sugar levels constant, so insulin levels generally rise after a meal, even in healthy people. Therefore, the question is whether the increase in insulin after meals has a negative impact on health.
In particular, consuming large amounts of carbohydrates can cause insulin levels to spike and lead to weight gain, which some experts say contributes to
However, Retnakaran said researchers disagree about the effects of postprandial increases in insulin, with some studies finding it harmful and others finding it beneficial. About. In particular, most studies on this topic have been conducted for short periods of time or are based on isolated insulin measurements, which can lead to insufficient considerations or incorrect conclusions, says Retnakaran. points out.
To find out how postprandial blood insulin levels affect cardiometabolic health, Retnakaran and colleagues tracked the health of a total of 306 pregnant women recruited between 2003 and 2014. We conducted research to Pregnant women were targeted because the insulin resistance that occurs during pregnancy can predict future risk of type 2 diabetes.
The key point of this research is that it uses an index called ``corrected insulin response (CIR),'' which corrects the insulin response by taking into account the level of sugar in the blood. Understanding the relationship between insulin levels and blood sugar levels is essential to understanding the effects of insulin on health, but until now attention has focused only on insulin levels, which has led to discrepancies in previous research. It is thought that this may be a contributing factor.
Pregnant women in the study underwent comprehensive testing, including a glucose tolerance test, one, three, and five years after giving birth. When the research team analyzed the test results of the participants, they found that those in the high CIR group had worse waist size, HDL (good cholesterol) levels, CPR (inflammatory marker) levels, and insulin resistance scores, but they had lower scores for
Furthermore, while high CIR does not correlate with BMI, waist size, lipids, inflammation, insulin sensitivity or resistance over the long term, high CIR is associated with beta cell function and low blood glucose levels. I was there. More importantly, women in the group with the highest CIR were also found to have a significantly lower risk of developing diabetes or pre-diabetes in the future.
'The results of this study challenge the idea that high postprandial insulin levels are inherently bad, and provide important information that deepens our understanding of insulin's complex role in regulating metabolism. 'This is a step forward,' commented LTRI principal investigator Anne-Claude Gingras, who was not directly involved in the study.
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