It was found that the risk of dementia increased with overdose of general medicines such as insomnia and hay fever

By* G

Some drugs used to alleviate symptoms such as insomnia and allergic rhinitis,Risk of causing dementia by taking too much over an extended period of timeIt was found that there was.

BBC News - Dementia 'linked' to common over-the-counter drugs
http://www.bbc.com/news/health-30988643

This report is a medical journal issued by the American Medical Association "Journal of the American Medical Association(JAMA) "published in. In a report that can be referred to from the following link, deal with insomnia, allergic rhinitis, depression, etc.Anticholinergic drugTo overdose over a long period of time by older people, the risk of developing dementia such as Alzheimer's disease dramatically increases has been revealed. However, another expert said "Should not panicI'm giving advice to you.

JAMA Network | JAMA Internal Medicine | Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study
http://archinte.jamanetwork.com/article.aspx?articleid=2091745


◆ Increased risk of developing with excessive intake
In general, all drugs have more or less side effects, which can be said of the anticholinergic drugs covered this time. Anticholinergic drugs, which transmit information in the brain,acetylcholineIs a drug that inhibits binding to the receptor, but it has been known for some time that symptoms such as mouth thirst and memory disorder exist as side effects.

According to the results of the research presented this time, it has been clarified that there is a causal relationship with such a situation that the risk of dementia is rising in addition to such side effects.

The research team of Shelly L. Gray medical doctor of Washington University who conducted the survey investigated the actual condition of the influence by tracking the health condition of 3434 subjects who are 65 years of age or older who do not show signs of dementia did. The team investigated the administration status of anticholinergic drugs from medical records and medication records of each subject. Then we compare the situation diagnosed as dementia and investigate the degree of its effect.

As a result, it was found that the most frequently taken drugs were antidepressants, antihistamines used as a sleep adjuvant to relieve the symptoms of hay fever, etc., incontinence suppression medicines, etc. Furthermore, about 20 % Can be purchased without requiring a doctor's prescriptionOTC drugs(OTC medicine) was found to have been clear. Of the subjects surveyed, 797 people developed symptoms of dementia.

ByBrice Ambrosiak

Based on the results of the survey, the researchers found that the risk of developing dementia increased was "1: 10 mg of antidepressant doxapine per day" "2: diphenhydramine as a sleep adjuvant 4 mg per day" "3 : 5 mg per day for oxybutynin contained in urinary incontinence drugs "for at least 3 years or more, and it is estimated that doctors and pharmacists should consider preventive measures and take other treatment policies I advise adoption. In addition, if another method can not be found, it is requested that administration of the above medicine should be done in a small amount and a short period as much as possible.

Dr. Gray has approved autopsy after death from several investigators and said, "I want to check if there is an influence that supports the results by investigating actual brain situation."

◆ Survey of actual cause and effect relation
To this result, in the UKAlzheimer's Research UK"It is an interesting result, but there is no proof that these drugs caused dementia, and it is not conclusive," said Dr. Simon Ridley of Dr. Simon Ridley (UK Alzheimer's Laboratory). In addition, Dr. Doug Brown of the Institute has said that concerns about similar risks existed before, "I do not know if it is still a reality or not, even if it is true, It is not clear whether it is due to taking a dose or a limited event caused by taking a short term "as a thorough investigation to accurately understand the risk of losing drugs It states the necessity to do.

Dr. Brown also suggests that physicians and pharmacists deepen their understanding of this potential causation relationship and those who are concerned about this subject first consult with their family doctor and take their medication at their own discretion I advise not to stop.

ByDaniel Foster

With regard to this issue, financial assistance for further investigation has begun to gather, and investigations will be conducted on the relationship between the above drugs and other drugs and the occurrence of dementia. Also, in the UKMedicines / Medical Product Regulatory Agency(Medicines and Healthcare Products Regulatory Agency) also focus on this trend.