Nov 20, 2023 23:00:00

What are the potential disadvantages that “intense exercise” brings to the body?

Moderate exercise has been shown to have a variety of benefits,

including improving sleep quality and reducing the risk of heart disease . On the other hand, it has been reported that strenuous exercise such as excessive training may make you more susceptible to viral respiratory infections.

Elucidating regulatory processes of intense physical activity by multi-omics analysis | Military Medical Research | Full Text
https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-023-00477-5

Vigorous Exercise, Rigorous Science: What Scientists Learned from Firefighters in Training | Feature | PNNL
https://www.pnnl.gov/news-media/vigorous-exercise-rigorous-science-what-scientists-learned-firefighters-training

Study Finds a Potential Downside to Vigorous Exercise We Didn't Know About : ScienceAlert

https://www.sciencealert.com/vigorous-exercise-may-have-a-concerning-effect-we-didnt-know-about

Ernesto Nakayas, a biomedical scientist at the Pacific Northwest National Laboratory (PNNL), and his colleagues collected blood, urine, and saliva samples from 11 firefighters immediately after a strenuous workout, and collected samples of proteins, lipids, and We analyzed metabolites, etc. The firefighters underwent grueling training during the day, wearing fireproof clothing, gloves, helmets, goggles and other equipment, and running around for 45 minutes while carrying around 20kg of cargo.

Christine Johnson from the research team said, ``The purpose of this study was to conduct a detailed analysis of what happens in the body after intense exercise, to see if we can quickly detect the dangers of fatigue. 'We wanted to find out. It may be possible to reduce the health risks of strenuous exercise for firefighters, emergency personnel, athletes, military personnel, etc.'

As a result of analysis by the research team, it was confirmed that ``

opiorphin '', which has the effect of dilating blood vessels, increased in firefighters who performed intense exercise. According to the research team, opiorphin may increase blood flow to muscles during exercise, allowing them to more efficiently deliver oxygen and nutrients. It has also been confirmed that saliva contains a decrease in signaling substances that are important for fighting off inflammatory reactions and viruses in the body.

A reduced inflammatory response allows you to breathe in more air, making it easier to get more oxygen into your body during intense exercise. In addition, even after intense exercise, it stabilizes breathing and improves blood flow.

On the other hand, when the inflammatory response decreases, the body becomes vulnerable to viral respiratory infections such as influenza, tuberculosis, and the new coronavirus infection. Previous studies have shown that people are up to twice as likely to contract a viral respiratory infection in the days following strenuous exercise. Nakayas said, ``Even healthy people may be more susceptible to viral respiratory infections immediately after intense exercise.The reason is that intense exercise weakens the immune system needed to fight off viruses.'' It's possible,' he said.

The research team used firefighters, whose immune responses may change due to exposure to chemicals during a fire, as subjects, and the subjects were all healthy men. It is pointed out that it is necessary to conduct analyzes with many subjects. Still, Nakayas says, ``We hope that this study will provide some insight into how strenuous exercise increases the risk of viral respiratory infections.''