Oct 11, 2023 07:00:00

What are the characteristics found in the blood of people who live longer than 100 years?

Humans have been thinking about the question 'What do we need to live a long life?' for thousands of years, and even today, when more and more people are living longer than 100 years, there is still no clear answer to this question. not. A new study conducted by a team at Sweden's

Karolinska Institute analyzed the blood of people over 100 years old and those who were not, and found that several blood biomarkers are associated with longevity. became.

Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort | GeroScience
https://link.springer.com/article/10.1007/s11357-023-00936-w

Centenarian blood tests give hints of the secrets to longevity
https://theconversation.com/centenarian-blood-tests-give-hints-of-the-secrets-to-longevity-215166

Humans have been exploring ``aging'' since the time of Plato and Aristotle , and scientists around the world are conducting research to find out what causes longevity. However, behind longevity there is a complex interplay of genetic factors and lifestyle, and the effects these have on a person throughout their life, and it is not easy to elucidate it.

To compare those who live longer than 100 years old with those who live shorter lives, a research team led by epidemiology researcher Karin Modiegh of Karolinska Institutet conducted health measurements at ages 64 to 99.4 We analyzed data from the AMORIS cohort study, which included 4,000 Swedes.

Participants in the AMORIS Cohort Study were followed for up to 35 years, and 1,224 of the 44,000 participants (2.8%) lived to be over 100 years old, with approximately 85% of those over 100 years old being women. About. Blood was also collected from the participants and 12 biomarkers related to inflammation, metabolism, liver and kidney function, malnutrition, and anemia were measured.

As a result of analyzing the data, it was found that people who live longer than 100 years old tend to have lower overall

glucose, creatinine , and uric acid values after their 60s. It has also been reported that people with extremely low total cholesterol and iron levels are less likely to live to be 100 years old.

Looking only at the median values, the differences in most biomarkers between those who lived longer than 100 years and those who did not were not significant, but those who lived longer rarely showed extremely high or low values. . 'For example, very few centenarians had blood sugar levels above 6.5% or creatinine above 1.25 mg/dl early in life,' Modiague said.

Although many biomarkers were more or less associated with the possibility of living up to 100 years, some biomarkers, such as uric acid, had a particularly strong relationship with lifespan. For example, people in the group with the lowest uric acid levels had a 4% chance of living to age 100, while people in the group with the highest uric acid levels had only a 1.5% chance of living to age 100.

Please note that this study only investigated the relationship between biomarkers and lifespan, and it is unclear what lifestyle or genetic factors are related.

'Even if the differences we found were fairly small overall, they suggest a potential link between metabolic health, nutrition, and exceptional longevity,' Modiague said. said.