Jul 09, 2022 21:00:00

Why do researchers claim that 'people should keep their poop in the'poop bank''?

In recent years, a treatment method called

fecal microbiota transplantation (fecal transplantation / FMT) that balances intestinal bacteria by transplanting the feces of another person to a patient has been attracting attention, and various diseases including inflammatory bowel disease (IBD) have been attracting attention. It is expected to be useful for treatment . Regarding such FMT, a research team of Harvard biologist Yang-Yu Liu and others insists that 'people should keep their feces in a cryopreservable facility.'

Rejuvenating the human gut microbiome: Trends in Molecular Medicine
https://doi.org/10.1016/j.molmed.2022.05.005

Experts Say We Should All Be Storing Our Poo in a Bank, And Here's Why
https://www.sciencealert.com/experts-say-we-should-all-be-storing-our-poo-in-a-bank-and-here-s-why

In general fecal transplantation, the donor and the patient are different, and the patient who has an imbalance of intestinal bacteria is treated by transplanting the feces of a donor who has healthy intestinal bacteria. However, the research team of Liu et al. Replaced the donor with 'the self when the intestinal bacteria were well-balanced at a young age' and the patient with 'the self when the intestinal bacteria were out of balance', and the donor and the patient were the same person. We are devising a fecal transplant system.

By matching the donor and the patient in fecal transplantation, the pathogen that was not a problem in the donor's body causes the patient to develop some kind of illness, the change in the intestinal bacteria causes a significant change in the constitution, and temporary adverse effects occur. It is said that the risk of sickness can be suppressed.

'A bank for autologous stool transplantation is conceptually similar to storing baby umbilical cord blood for the future,' Liu said. 'But the stool bank has great potential and uses stool samples. I expect it to be much more likely than umbilical cord blood. '

There is already a 'feces bank' that stores human feces, and similar facilities have been opened all over the world since

OpenBiome , the first non-profit feces bank, opened in Massachusetts, USA in 2012. And that. These fecal banks assume that the donor and the patient are separate, but in principle similar fecal sampling and storage and transplantation processes can be used for autologous fecal transplantation.

The research team said, 'Similar procedures in host screening and sampling can be used to rejuvenate gut bacteria by autologous fecal transplantation.' It can be diverted to the idea of rejuvenating gut bacteria with a fecal transplant. '

Co-author epidemiologist Scott Ways said, 'Autologous fecal transplantation treats autoimmune diseases such as asthma, multiple sclerosis, inflammatory bowel disease (IBD), diabetes and obesity, as well as heart disease and aging. It has potential. '' We hope this paper encourages long-term trials of autoimmune transplantation to prevent disease. '