The largest clinical trial ever to administer ivermectin to patients with new corona reiterates that 'ivermectin has no therapeutic effect on new corona'
Early in the epidemic of the new coronavirus infection (COVID-19),
Effect of Early Treatment with Ivermectin among Patients with Covid-19 | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMoa2115869
Ivermectin Does Not Reduce Risk of Covid Hospitalization, Large Study Finds --The New York Times
https://www.nytimes.com/2022/03/30/health/covid-ivermectin-hospitalization.html
Ivermectin worthless against COVID inlarge clinical trial to date | Ars Technica
https://arstechnica.com/science/2022/03/largest-trial-to-date-finds-ivermectin-is-worthless-against-covid/
Papers published in the New England Journal of Medicine, a medical journal, were randomly selected COVID-19 from March 23-August 6, 2021 at 12 public health clinics in Brazil. This is an analysis of the results of clinical trials in which ivermectin is administered to patients.
More than 1,300 COVID-19 patients were enrolled in this clinical trial, with 679 randomly selected patients assigned to the 'Ivermectin-administered experimental group' and 679 to the 'placebo-administered control group.' Assigned. All enrolled patients were 18 years of age or older and developed COVID-19 within 7 days of being tested positive for the new coronavirus, as well as '50 years of age or older,' 'diabetes,' 'hypertension,' and 'cancer.' At least one, such as 'lung disease,' had factors that increased the risk of COVID-19.
Patients were assigned to each group after they were found to be positive for coronavirus, and for 3 days from that point, the experimental group took '400 micrograms per kg of body weight' of ivermectin and the control group took placebo. .. The study team, facility staff, and patients were not informed about the randomization, ivermectin and placebo were packaged in the same bottle, and only the pharmacist responsible for the randomization could identify the drug based on the alphabet on the bottle. It was. Initially, the dose of ivermectin was lower, and the number of days of administration was planned to be only one day, but the research team said that the dose and the number of days were increased in response to 'feedback from the advocacy group of ivermectin'. increase.
All patients were treated according to the general treatment protocol in Brazil, except that they were given ivermectin or placebo. The research team monitored the patient's condition face-to-face and in a video conference for 28 days to analyze how the pathology of COVID-19 differs between the experimental and control groups.
Analysis of the results of clinical trials did not confirm that administration of ivermectin reduced situations such as hospitalization or long-term observation in the emergency department. In addition, COVID-19, such as the time to recovery, the time to become negative in the PCR test, the time spent in the hospital, the need for mechanical ventilation, the duration of mechanical ventilation, the time to death, and the time to death. The research team reports that it did not affect all secondary outcomes.
'(Ivermectin does not bring any benefit) in the treatment of COVID-19,' Dr. David Boulware, an infectious disease expert at the University of Minnesota, who co-authored the paper, told the New York Times. Now that detailed data is available, the vast majority of doctors will hopefully move from ivermectin to other treatments. ' Several clinical trials of ivermectin are still underway at the time of writing, but because this clinical trial is fairly large and carefully designed, 'I don't think we'll get any different results.' Boulware said.
Regarding ivermectin, there is intense online debate about the therapeutic effect of COVID-19. It is also reported that medical insurance companies were forced to spend an additional $ 129 million a year due to the sharp increase in ivermectin prescriptions in the United States in 2020.
In a prison in Arkansaw, USA, a lawsuit was filed for side effects such as diarrhea, bloody stools, stomach cramps, and visual abnormalities caused by the administration of ivermectin to prisoners without permission. More and more people are overdose by taking ivermectin for livestock because they couldn't get it, leading to an official warning from the U.S. Food and Drug Administration (FDA) that 'you are neither a horse nor a cow.' increase.
The number of Americans who drink ivermectin for livestock has increased rapidly as a countermeasure against the new corona, and the authorities officially warn that 'you are neither a horse nor a cow' --GIGAZINE
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