Possibility to repel the new coronavirus with the idea of 'hit the corona against the corona'
A paper has been published that it may be possible to counter the new coronavirus infection (COVID-19) by using an artificially synthesized 'harmless defective product of the new coronavirus (SARS-CoV-2)'. I did. This 'synthetic defect virus' self-replicates three times faster than SARS-CoV-2 and blocks the growth of SARS-CoV-2, so it can be expected as a new treatment for COVID-19. ..
A synthetic defective interfering SARS-CoV-2 [PeerJ]
Fighting COVID With COVID: Driving the Disease to Extinction With a Defective Version of the SARS-CoV-2 Virus
https://scitechdaily.com/fighting-covid-with-covid-driving-the-disease-to-extinction-with-a-defective-version-of-the-sars-cov-2-virus/
COVID-19: Synthetic virus could'parasitize' SARS-CoV-2
https://www.medicalnewstoday.com/articles/can-we-fight-sars-cov-2-with-sars-cov-2
In a newly published treatise, a research team led by Marco Arketti, an associate professor of biology at Penn State University, has shown the potential of treating COVID-19 with a defective virus. .. According to Mr. Arketti, when a virus such as SARS-CoV-2 attacks human cells, it first attaches to the surface of the cell and injects the genetic substance into the cell. Then, the cells are hijacked to replicate a large amount of viral genetic material, and finally, innumerable virus particles are released from the collapsed cells, further expanding the infection in the human body.
Repeated replication of the virus in the host body can, in rare cases, fail to synthesize genetic material and result in the loss of part of the virus's genome. When the genome is missing, the virus cannot grow normally because it cannot synthesize the proteins needed to behave as a virus. However, when a normal virus arrives at a cell containing a defective virus, a phenomenon may occur in which the genome of the defective virus proliferates using the genome of the normal virus and replaces the normal virus. I have.
The function of a virus with a defective genome to prevent the growth of a normal virus is academically
The research team of Arketti et al., Who focused on the fact that DI particles block the growth of viruses, developed 'SARS-CoV-2 DI particles' by cutting the SARS-CoV-2 genome by 90%. An experiment was conducted in which the DI particles were added to wild-type SARS-CoV-2, that is, monkey cells infected with normal SARS-CoV-2. As a result, the amount of normal SARS-CoV-2 is reduced by half 24 hours after the start of the experiment, while the 'DI particles of SARS-CoV-2' are three times faster than normal SARS-CoV-2. It was confirmed that it proliferates in.
'DI particles do not function as SARS-CoV-2 due to their deficiency and cannot grow on their own,' Arketti said. However, when infected with wild-type SARS-CoV-2, SARS- It hijacks the CoV-2 growth process to replicate DI particles, and because of its short genome, it self-replicates faster than SARS-CoV-2 and blocks SARS-CoV-2 growth. ' explained.
A 50% reduction in SARS-CoV-2 does not lead to treatment for COVID-19, but the research team is able to proliferate 'DI particles of SARS-CoV-2' faster than SARS-CoV-2. Expects the effectiveness of DI particles to increase over time.
Arketti emphasized that further experiments are needed to verify whether 'SARS-CoV-2 DI particles' can be used as antiviral drugs. Synthetic DI particles have the potential to be used as a treatment for COVID-19. '
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