Experiments with mice revealed that "whole blood tumor disappears by" cancer vaccine "

New treatments are also reported in the treatment of "cancer" who is suffering many people. The research team at Stanford University has announced that by directly injecting two immune system stimulants into the tumor of the mouse, it was able to eliminate not only the site but also the tumor that was dispersed throughout the body.

Cancer 'vaccine' eliminates tumors in mice | News Center | Stanford Medicine
https://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates-tumors-in-mice.html

Since "side effects" are often found in "anticancer drugs" that are often used in cancer treatment, it is said that certain risks are involved. However, according to the method developed by the research team of Stanford University this time, it is possible to effectively reduce the tumor and to eliminate it by directly injecting two very small amounts of drugs into the tumor site.

This medicine consists of substances that stimulate the body's immune system, and Dr. Ronald Levy, professor of oncology, said about its effect "This approach requires the need to identify tumor-specific immunotarget We do not need to activate the immune system extensively or customize it according to the patient's immune cells, "he stated the difference from conventional therapy. Dr. Levy is a pioneer of "cancer immunotherapy" that utilizes the body's immune system for cancer treatment, and is an antibody drug (monoclonal antibody) used for treatment of malignant lymphomaRituximabIt is a person who has led the development of 'something.


The method used this time works on certain cancer cells by injecting two kinds of medicines at a part of the tumor at a millionth of gram level respectivelyT cellsIt activates. One of the two drugs, what is called "CpG oligonucleotide", works with other nearby immune cells to amplify the expression of activating receptor called OX40 on the surface of T cells. And the other is an antibody that binds to OX40 and is used to activate T cells to lead to attack against cancer cells. Since these two drugs are injected directly into the main part, only the T cells in that part are activated.

When this approach was performed with experimental mouse, remarkable results were confirmed. When grafts of lymphoma tumors were implanted in two places in the mouse and two drugs were injected into one tumor site it was found that not only the treated tumor but also a second untreated tumor located elsewhere in the body However, it seems that regression of the organization was seen. It has been confirmed by this treatment that 87 of the 90 mice have healed the cancer. In addition, cancer recurred in 3 mice, but it was confirmed that the tissue became small after the second treatment. This result seems to be similarly confirmed in mice with breast, colon and melanoma tumors.

It is also known that mice genetically engineered to spontaneously develop breast cancer in all 10 breast tissues also responded to this treatment. It is also known that by treating the first tumor, it is possible to prevent the development of future tumors and to significantly extend the life span of individuals.

ByDr. Partha Sarathi Sahana

In order to obtain more detailed data, the research team is investigating the specificity of T cells by transplanting two types of tumors into mice. To the mouse, first transplant the same lymphoma cancer cells as the original, then transplant the colon cancer cell line to another place. Treatment with another tumor cell was done in this way, only colon cancer cells were not affected. In other words, it was confirmed that it is a method capable of attacking only specific cancer cells. "This is a very targeted technique," Levy said, "I am attacking specific targets without accurately identifying the proteins that T cells recognize."

In the future, Dr. Levy plans to conduct clinical trials by recruiting about 15 patients with low-grade lymphoma. If this is successful, Dr. Levy believes that this treatment will be useful for many tumor types. Levy says, "As long as it is attacked by the immune system, we do not think there is a limit to the types of tumors potentially treatable."