Findings that antiparasitic drugs stop replication of new coronaviruses within 48 hours



Research has shown that a drug called ivermectin, which is already widely used as an antiparasitic treatment, stops replication of a novel coronavirus (SARS-CoV-2) within 48 hours. Although this study is based on in vitro experiments, ivermectin has already been shown to be safe for humans and, depending on the results of clinical trials, appears to be a promising drug for COVID-19.

The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro-ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0166354220302011

Possible coronavirus drug identified by Monash University scientists-Monash Biomedicine Discovery Institute
https://www.monash.edu/discovery-institute/news-and-events/news/2020-articles/possible-coronavirus-drug-identified-by-monash-university-scientists

Coronavirus fight: possible COVID-19 drug identified by scientists-Monash University
https://www.monash.edu/news/articles/coronavirus-fight-possible-covid-19-drug-identified-by-scientists

Ivermectin is used as an antiparasitic treatment for head lice and other diseases, and a research team at Colorado State University in 2019 said that `` it is effective for malaria control because the blood of the recipient is toxic to mosquitoes '' Also announced.

Drug `` ivermectin '' that makes mosquitoes who suck blood die will reduce malaria by as much as 20%-gigazine



Researchers at the University of Monash University's Biomedicine Discovery Institute (BDI), Dr. Kylie Wagstuff and others, will stop replication of SARS-CoV-2 cell-cultured ivermectin in a laboratory setting within 48 hours I figured it out. 'We found that a single dose could remove all RNA in less than 48 hours, with significant reductions occurring in less than 24 hours,' said Dr. Wargustaf.

Although this study is not in clinical trials, ivermectin is considered a safe substance for the human body because it is a widely used drug. Ivermectin has been shown in vitro to be effective against parasites as well as HIV, dengue virus, and zika virus.

The mechanism by which ivermectin acts on SARS-CoV-2 is unknown, but the researchers have found that the virus `` prevents host cells from removing the virus, '' just as it does with other viruses. It is thought that there is a function to stop the ability to.

Dr. Leon Kelly, one of the authors of the paper, said, `` Ivermectin has potential for COVID-19 drugs as one of the first virologists in the research team to isolate SARS-CoV-2 outside China in January 2020. I'm excited about it. ' In addition to Dr. Wagstaf, the research team includes Professor David Jans, a researcher who has been studying ivermectin for over 10 years. When Jans and Dr. Waagstaf found out that the pandemic had begun, they immediately began investigating the effects of ivermectin on SARS-CoV-2.

Although ivermectin is said to be safe for the human body, the decision to use it for COVID-19 depends on the results of clinical trials. Researchers have called for urgent funding to continue their research.

in Science, Posted by logq_fa