A genetic mutation that causes left-handedness is identified
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“Left-handed” people who use their left hand reflexively are said to be around 10-30% of the total population, although they may be corrected and vary. The reason why left-handed people are born is not clear, but some studies have hypothesized that handedness is inherited. Meanwhile, a research team at Oxford University announced that it has identified the location of genetic mutations related to left-handedness.
Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics | Brain | Oxford Academic
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz257/5556832
Genome Regions Associated With Left-handedness Identified For the First Time | Technology Networks
https://www.technologynetworks.com/genomics/news/genome-regions-associated-with-left-handedness-identified-for-the-first-time-323619
The fact that left-handed people have existed since the Paleolithic period is indicated by the shape of the stone tools and how the murals are drawn. However, there seems to have been an idea that it should be right-handed for a long time, and according to the explanation of the Kyoto National Museum , in Africa and South Asia, left-handed is straightened by putting the left hand in hot water or tying it up. There was a race to try. Also, in the 17th century, it was believed that 'the devil baptizes with his left hand', so left-handed people were seen as worshipers of the devil.
19th-century Italian psychiatrist Cesare Lombrozo , founder of criminal anthropology and also called 'father of criminology', advocates the criminal criminal theory that criminals tend to be criminalized by innate nature , He argued that 'left-handed people prefer the right brain over the left brain and tend to be criminal in nature.' It is believed that the movement to correct left-handedness has spread throughout society through these claims. In addition, Lombrozo's innate criminal theory is almost denied from the viewpoint of modern science.
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Oxford University researchers have analyzed the genome of about 400,000 people registered with the UK Biobank . In this sample, there were 39,332 left-handed people. Genome-wide association analysis based on this information revealed that four single nucleotide polymorphisms (SNPs) rs199512 , rs45608532 , rs13017199 , and rs3094128 are related to left-handedness.
The human gene is a blueprint for proteins, and is encoded by a sequence of four types of nucleotides : adenine, thymine, guanine, and cytosine that make up deoxyribonucleic acid (DNA). SNP is a sequence variation found in a small part of the code, and contributes to individual diversity.
Among the identified SNPs, rs199512 was located in a gene that expresses proteins related to brain development and neuronal axon guidance. The research team linked the brain biographs of people registered with UK Biobank, and these SNPs made the difference in the structure of the white matter that is the tissue in the brain from the stage of the cytoskeleton, and the dominant hand left Is n’t it? ”
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The research team also found that left-handed subjects exchanged signals more smoothly between the language areas on the left and right sides of the brain. However, “This raises an interesting possibility of future research that left-handed people may be advantageous in performing language tasks, but this difference is only among many people. “It's average, and left-handed people don't always have good language skills,” the research team said.
In addition, there was a statistically significant positive correlation between left-handedness and schizophrenia and Parkinson's disease. The
Professor Guenel Duau, who studies functional brain imaging at the University of Oxford, said, “It was the first time that humans showed the difference in the cytoskeleton in the brain in relation to the dominant hand. And it was known in frogs. ' In fact, a Japanese researcher announced in May 2019 that he succeeded in mutating snail shells to the left by CRISPR, a gene editing technology.
A phantom `` left-handed snail '' with only one in 10,000 is born with gene editing technology CRISPR-GIGAZINE
Professor Dominique Farnis of Oxford University, the co-author of the paper, said, “Through history, left-handed people have been considered unlucky and even malicious. Is a result of science and has shown that some of it is driven by complex interactions of many genes, which is part of the diverse tapestry that makes us human. ' .
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