Gene editing technology CRISPR is born with a phantom 'left-handed snail' with only one in 10,000
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The snail is a type of snail, and most individuals carry the right-handed shellfish on their backs, but it is known that a snail whose left-handed shellfish is one per 10,000 exists. A research team led by Japanese biophysicist Atsuko Kuroda, who is not the direction of shellfish but also the viscera, is a research team led by Japanese biophysicist Keiko Kuroda, who mutates the snail to the left with Gene Editing Technology It is reported that 'It succeeded.'
The development of CRISPR for a mollusc established thes the formin Lsdia1 as the long-sought gene for snail dextral / sinistral coiling | Development
http://dev.biologists.org/content/146/9/dev175976
The most famous left-handed snail is Jeremy, a snail found in compost in the United Kingdom, which once became a topic of having been recruited as a matchmaker via SNS. It seems that a matchmaking partner was found, but Jeremy seems to have died in 2017 immediately after that.
In May Born, The First Of Tomeu'S And Lefty'S Children Are Just Reaching Adulthood. Pic.Twitter.Com/uOqhFVqT28
— Jeremy the snail (@leftysnail) December 20, 2017
A research team led by Mr. Kuroda argued that a gene called 'Lsdia1' was to be determined about the winding direction of the shellfish of the European monopod Ally (Lymnaea stagnalis). At the same time, a research team led by Angus Davison biology professor at the University of Nottingham also pointed out the involvement of Lsdia1 separately from Mr. Kuroda.
The research team led by Mr. Kuroda is based on the hypothesis that, even if Lsdia1 is lost, the clamshell, which is essentially right-handed, will be left-handed by the replacement of the nearly identical gene 'Lsdia2'. A gene editing technology, CRISPR, was used to prepare the European monosnail embryo from which the Lsdia1 gene has been deleted. Then, when the embryos repeatedly undergo cell division and reach the 8-cell stage, differentiation has begun in the opposite direction from the original.
As a result, it is said that European monosnails in which Lsdia2 was expressed instead of Lsdia1 and its offspring became left-handed. Mr. Kuroda stated, 'I would like to find out if the left-handed snail will become the dominant change for the right-handed snail.'
According to Professor Davison, who also studies left-handed snails, there is probably no universal gene that changes the asymmetry of any organism, but a system for constructing the asymmetric cellular structure of all organisms is possible. It has sex. 'We're trying to figure out why snails are left-handed, but unfortunately, research on snails doesn't progress quickly,' said Dravison.
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