Attempt to create a snake venom panacea from men who have been bitten by poisoned snakes for many years
Some types of snakes have a life-threatening virulence, and a large number of people die from being bitten by snakes every year. However, there are some who daringly get bitten by poison snakes or administer poisons to produce serum against snake venom in their own body, and based on the antibody possessed by that person, poison snakes are Attempts are underway to create a universal
The Human Antivenom Project | Outside Online
https://www.outsideonline.com/2395803/snakebite-antivenom-tim-friede
By around 2000, Tim Fried, a track mechanic in Wisconsin, USA, came to have the idea of taking various poisons into the body and providing scientists with blood to make a universal antitoxin. I was caught in poison by 200 kinds of snakes by the time.
When the poison enters the body, the immune system reacts and produces an antibody that makes the B cell lose the effect of the poison, but if bitten by a poison snake, it may die before the antibody is produced. So, Mr. Fried extracts and dilutes a small amount of poison from the poisoned snake that he has obtained and administers it to the body. He slowly produced antibodies against the poison in his body.
However, since it is not always possible to obtain a complete antibody just because one dose of poison was given, Mr. Fried had to change the dilution concentration and inject the same poison many times. Also, because there is another poison that combines 20 to 70 proteins and enzymes for each poison snake, Mr. Fried has collected dozens of poison snakes from around the world to produce even a complete antibody. Sometimes, I was bitten by poisoned snakes twice a day, and I was in a coma for four days.
by
Mr. Fried did not earn serious attention from medical researchers although he appeared on a local radio program and responded to television coverage to fulfill its original purpose of 'making it a universal antitoxin.' .
Still, Mr. Fried continued to inject the poison without hesitation, and when he felt that he had enough antibody, he kept going directly bitten by the poisoned snake. The bites of poisonous snakes were published on the YouTube channel , but the comments received were 'poor' and 'I wonder if I'm getting rid of it'.
Symptoms of snake venom that Mr. Fried experienced include 'swelling of 3 cm square' 'swelling from knee to buttocks' 'hives of whole body' 'anaphylactic shock'. In the meantime, Mr. Fried has acquired the ability to distinguish how much poison has been injected based on his symptoms and pain.
It was immunologist Dr.
After Pfizer's retirement, Dr. Granville launched a company called Distributed Bio , which licensed software to find libraries of antibodies and compatible combinations. And I increased the staff, also embarked on the development of influenza vaccine etc. Dr. Granville, who was also interested in producing snake venom sera, was Mr. Fried's 'must-seek'.
The World Health Organization (WHO) classified poisoned snake damage as 'a neglected tropical disease' in June 2017, when it was almost time for the two to make contact. There are 80,000 to 130,000 deaths a year due to poisoned snakes, and 400,000 have been forced to cut their limbs for treatment.
by Icewall42
The disadvantage of serum against snake venom is that the antibody is effective against only one poison. For example, in the US there are 4 types of dangerous poison snakes, so 4 types of serum should be prepared. In India, there are 60 types of dangerous poison snakes, so serum for all poisons is prepared. Difficult to do. Another problem is that serum is very expensive because it expires in 2 years.
However, Dr. Granville analyzed the genome of 700 poisonous snakes and found that lethal proteins can be classified into 13 types. Furthermore, instead of preparing antibodies against all proteins contained in snake venom, we came to the idea of preparing only antibodies that were effective for lethal proteins.
The key to Dr. Granville's thinking is the presence of Mr. Fried, who has incorporated many snake venoms into his body. When Dr. Fried's antibody was tested in the laboratory, it turned out that it is also effective against poison snake poison that Mr. Fried has never been bitten.
Distributed BIo and the US National Institutes of Health jointly set a $ 400,000 budget in December 2018. Finally, a long-awaited request came into effect, and a project to generate snake venom serum from antibodies in Mr. Fried's body started in earnest. Since this serum uses human-derived antibodies, it is possible to suppress rejection and to be able to be carried easily by dehydration and powderization.
However, since the drug development has a very low success rate, it seems that investment from investors is not good, but Dr. Granville says, “If serum can be made with Tim's antibody, why 130,000 people die from snake venom 'Do you have to do it?'
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