A contraceptive method for men inspired by cocktails will be developed

by Steve Bennett

As a method of contraception during sexual activity, wearing a condom or taking a pill can be mentioned. Women can control contraceptives over the medium to long term by taking pills, while male contraceptive methods are temporary to put on condoms or extreme two choices as to whether to make a pipe cut to completely disable reproductive behavior It is the state. Meanwhile, contraceptive methods for men inspired by cocktails were developed by Chinese researchers.

A Cocktail-Inspired Male Birth Control Strategy with Physical / Chemical Dual Contraceptive Effects and Remote Self-Cleared Properties - ACS Nano (ACS Publications)
https://pubs.acs.org/doi/10.1021/acsnano.8b06683

Layered cocktails inspire new form of male birth control - ScienceDaily
https://www.sciencedaily.com/releases/2019/01/190130133209.htm

Cocktail-Inspired, Injectable Male Birth Control Could One Day Dissolve Away with Light
https://www.livescience.com/64646-injectable-male-birth-control-dissolves-infrared.html

A research team of Nanchang University biologist Xiaolei Wang et al. Wanted contrivance for a relatively long period of time and wanted to devise a contraceptive method for men who can regain reproductive ability again when necessary It was. In the case of men, it is difficult to control birth control in the medium to long term like a pill for women, once it is cut off, it is difficult to regain reproductive ability again.

Therefore, the research team focused on layered cocktails like Pooze Cafe . Layered cocktails are divided into several layers at the time of provision, but they have the property that cocktails mix uniformly by stirring cocktails or adding heat.

by DM

Mr. Wang thought that it would be possible to inject a substance into layers in order to block the male vas deferens and block the sperm from reaching the urethra with the same mechanism as this. The research team used experiments with rats and tested the approach that was invented in practice.

In the experiment, gold nanoparticles were first injected into the vas deferens, then ethylenediaminetetraacetic acid (EDTA) and calcium alginate gel , finally gold nanoparticles were injected to form a 4-layer sperm barrier . By sequentially adding these substances, it seems that the calcium alginate gel not only physically occludes the vas deferens, but also it can make a double barrier that EDTA chemically kills the sperm.

According to the research team, rats injected with substances lost reproductive ability for more than two months. In order to restore the reproductive ability of rats, it is better to irradiate with near infrared ray for several minutes. By irradiation of near infrared light, gold nanoparticles injected so as to sandwich EDTA and calcium alginate gel are overheated, and the layer is mixed The research team explains when dissolving it. It seems that the time from the irradiation of near infrared ray to regain reproductive ability is also dependent on the amount of injected substance, but the reproductive ability of the rat has recovered in approximately 1 to 2 weeks.

by rawpixel.com

Catherine VandeVoort, director of reproductive endocrinology and infertility research at the National Center for Primate Research at California, believes that attempts to control male fertility by injection of substances and near infrared radiation are very attractive.

Meanwhile, VandeVoort pointed out that research requires more detailed investigation of the contraceptive period described by the research team "more than two months". In addition, we decided to investigate the reason why the rats who did not receive near-infrared irradiation again got reproductive ability, whether the layers were mixed by body temperature, or whether the substance layer itself was self-destructed.