Why do people not feel 'pain' at all in the world? If you ask why, it will lead to the next generation of analgesics

By lauren rushing

Even if you receive the same stimulus in your body, the "pain" you feel with it is in fact a lot of different, there are also people with " painless " that rarely feel pain in the world. Pain is one of the very important sensations for the survival of living beings, but there is a difference in sensitivity, there is a gene level mechanism there.

Why do some people hurt more than others?
https://theconversation.com/why-do-some-people-hurt-more-than-others-99995

As is well known, in the cells of the body, the human genome corresponding to the design as an individual is contained, and our body is formed based on that information. Among the DNAs contained in it, genes that are the blueprints of the proteins that make up the body are contained, but it is known that this gene is mutating little by little.

This mutation manifests in several forms, but the most common one is called a single nucleotide polymorphism or "SNP". SNP is a mutation occurring in a single unit constituting DNA.

By Genomics Education Program

There are about 10 million known SNPs in the human genome. As a guideline, if the rate of SNP exceeds 1% and is considered "general", that mutation is called a "variant", but if it is less than 1% it is called a "mutation" It will be. One of the symptoms caused by this mutation is "painless" which does not feel any pain at all.

The most common cause of painlessness is associated with the gene "SCN 9 A" that encodes the protein channel necessary for conveying pain information. It is necessary for the ion channel called sodium channel to operate in order for pain information to be transmitted through the nerve, but SCN 9 A sometimes invalidates the operation of this sodium channel. If the nerve signal is not transmitted, even if you fall down and crack your knees, you will not feel pain even if you fall down and hit your head, so the perception of your body being wounded may be delayed. Furthermore, since it is impossible to notice the invisible abnormality in the body such as chest pain due to a heart attack or appendicitis pain, the disease can not be found and the risk of becoming too late if you notice rises dramatically I will.

By CJS * 64

Mutations within SCN 9 A can cause not only painlessness but also its opposite symptoms. Two serious symptoms that feel extreme pain "Primary limb erythermia" and " Hereditary sensory autonomic neuropathy " are also mutations in SCN9A, and more pain signals than normal It is said that it will be swept by nerves.

Both of these symptoms are said to have great influence by heredity, and it is said that about 60% of the total is brought about by inheritance from the parent. It is unrelated to SCN 9A this time, but the six Marsili family living in Italy are in a state of not feeling any pain at all in common. It has been found by survey that this is a case brought by mutation of ZFHX2 gene.

"Families who do not feel pain" exist, what is the cause? - GIGAZINE
https://gigazine.net/news/20180114-family-doesnt-feel-pain/

Actually, Marsili does not feel pain at all, but he seems to be able to perceive pain only for a few seconds. Therefore, Ludovico, a 24-year-old son, went back to the game immediately even in a dangerous contact play while playing soccer, and it is good that a small crack has entered a lot of ankle bones without knowing I will.

The presence of analgesia due to such a mutation may bring important hints for developing new analgesics in the future. Patients who are suffering from chronic pain whose genetic mutation continues to feel pain all the time, there are many cases that they will take the highly toxic analgesic "opioid" for a stronger effect, but at the gene level As research progresses, there is no toxicity and it is expected to develop highly effective analgesics suitable for personal pain level.

By Britt-knee