Drug poisoning proved to be correlated with 'viruses externally entered into human genome'

by Todd Huffman

In fact, a certain number of viruses contaminated from the outside have entered the human genome and are inherited as part of the genome. The exogenous genomic sequence that is considered to be derived from " retrovirus " is called " endogenous retrovirus " and thought to have had a big influence on the human brain, but such an endogenous retrovirus correlates with drug intoxication A research result reporting that there is a relation was reported.

Human Endogenous Retrovirus - K HML - 2 integration within RASGRF 2 is associated with intravenous drug abuse and modulates transcription in a cell - line model | PNAS
http://www.pnas.org/content/early/2018/09/19/1811940115

Evidence that addictive behaviors have strong links with ancient retroviral infection - ScienceDaily
https://www.sciencedaily.com/releases/2018/09/180924174503.htm

In the human genome, endogenous retroviruses that have been inherited since invading long ago are scattered. Many human endogenous retroviruses are inherited in the same way for all humans, but for some endogenous retroviruses there are individual differences in the proportion of contamination to the genome.

In a study conducted jointly by Oxford University and the University of Athens , "When HERV - K HML - 2 (HK 2 ), a type of endogenous retrovirus, is present near the gene associated with dopamine release (RASGRF 2) It is discovered that there is a significant correlation that "it tends to be a drug addict."

The research team analyzed HK2 contamination in the genome of subjects infected with hepatitis C and AIDS in England and Greece. The route that these subjects were infected with the disease was identified as "drug injection", and both have people who have experienced drug addiction. In general, the proportion of HK2 present near the RASGRF2 gene is between 5 and 10%, but in the analysis of subjects who were drug addicts, the ratio of RASGRF2 gene It seems that HK 2 was present nearby. The research team thinks that there is a significant correlation between the presence of HK2 near the RASGRF2 gene and the fact that it is drug addiction.

by Pixabay

Professor Aris Katzourakis of Oxford University who commanded the research, "To date, there have been many things that people do not know about how retroviruses with individual differences are affecting the human body, The research first showed the world that HK 2 influences human characteristics. "

Although it was pointed out that "human's endogenous retrovirus is a factor that causes disease," the theory that endogenous retroviruses are harmless was common. It is unthinkable that endogenous retroviruses were contaminated into the human genome before modern people were born and that "HK2 increased near the RASGRF2 gene as drug poisoning".

While many human endogenous retroviruses are commonly present in many people, there are individual differences in HK2 contamination into the genome. Human endogenous retroviruses use replication signals generated by humans as hosts for self-replication. In that case, it may affect the expression and function of the genome that exists nearby, and it has been confirmed that contamination of HK2 has a great influence on the transcription of the nearby genome. The research team says that by studying the influence of HK 2 on the human body more deeply, it may be possible to use it for the development of drug addiction medicine.

by Karl-Ludwig Poggemann