Osteoarthritis caused by obesity is caused not by weight gain but by high fat diet

OsteoarthritisIt is an illness that affects about 8 million people in the UK and about 31 million people in the U.S. Also, it is known that osteoarthritis is highly likely to be caused by obesity, so far it was thought that the increase in body weight caused a burden on joints and wearing cartilage. However, it is not an increase in body weight that causes osteoarthritis, but rather due to unhealthy intestinal bacteria accumulated when a high-fat diet is given, Eric Scott of the University of Rochester The research team has shown.

JCI Insight - Targeting the gut microbiome to treat the osteoarthritis of obesity
https://insight.jci.org/articles/view/95997

Junk food-loving bacteria, not extra weight, cause arthritis and joint problems, study finds | The Independent
https://www.independent.co.uk/news/health/fat-obesity-arthritis-junk-food-probiotic-knee-cartilage-wear-inflammation-study-a8312366.html

Intestinal bacteria that breed by a high-fat diet cause inflammation triggered by a human being's stress and virus entering. When inflammation occurs, the immune system attacks joint cells and cartilage. At this time, the knee often becomes the target of attack, and the cartilage of the knee is easy to wear.

Michael Zushik, who participated in the study said, "Cartilage has the role of both cushion and lubricant and it supports the movement of frictionless joints. If you lose cartilage, direct contact between bone and bone, In other words, it will be in the same state as rock and rock rub against each other, it will be necessary to exchange the entire joint as it can not be backtracked in that case.In order to prevent this, researchers of osteoarthritis, I am making an effort to keep it. "

ByLena

In the research, we are conducting experiments with mice, and by giving a high-fat diet to mice, fat is doubled and diabetes is caused. Then, in this mouse, the inflammation-inducing bacterial level was higher than that of a fat fed diet, and wear of the knee cartilage progressed faster.

The research team has also confirmed ways to reduce cartilage wear and encourages the growth of bifidobacteriaFructo-oligosaccharideIt is known that by giving a prebiotic supplement called so, wear of cartilage can be avoided. Indeed, it has been confirmed that mice given supplements do not cause abnormal abrasion in the joints compared to mice that were not administered, and the degree of inflammation is reduced.

However, it is unclear whether incorporating "fructooligosaccharide" will produce the same effect in the human body, so further research is necessary.