A clinical trial application using genomic editing technology "CRISPR / Cas 9" that manipulates human genes will be approved

ByDave Fayram

Genomic editing technology expected to play a major role in future cancer research "CRISPR / Cas 9 (Crispa Cassine)The application for clinical trials utilizing the "Recombinant DNA Advisory Committee (RAC)" by the National Institutes of Health (NIH) passed the deliberation.

First proposed human test of CRISPR passes initial safety review | Science | AAAS
http://www.sciencemag.org/news/2016/06/human-crispr-trial-proposed


First Human Test of CRISPR Proposed
https://www.technologyreview.com/s/601717/first-human-test-of-crispr-proposed/

Gene-editing tool CRISPR may soon be used to treat humans for the first time | The Verge
http://www.theverge.com/2016/6/22/11998546/crispr-human-trial-approved-treat-gene-editing

The council was live streaming delivery on the net, attention gathered.

NIH Video Cast - Recombinant DNA Advisory Committee - June 2016 (Day 1)
https://videocast.nih.gov/summary.asp?live=19349


"Genome" means "genes (GenE) "and" chromosome (chromosOme) "In a word, it is all genetic information of DNA. If you read and understand the genome you will be able to know the function of the organism, but furthermore, it is expected that by editing the genome, it will treat diseases and create ideal living organisms, It is done.

What technology is "genome editing" in God's domain that can freely design genes and change the characteristics of living things? - GIGAZINE


In the field of "genome editing", a technology "CRISPR / Cas 9" that can manipulate arbitrary places of the genome sequence appeared in 2012. It became much easier to handle than genomic editing technology "ZFN" "TALEN" which was already there.

In this way, it is self-evident that thinking that "CRISPR / Cas 9" can be applied to human beings, it will be possible to conduct research that is useful for disease treatment more efficiently. The University of Pennsylvania makes attacks and treats T cells removed from the cancer patient's body against tumors such as myeloma (melanoma), melanoma, sarcoma (sarcoma) by genetic editing The proposal was made, and deliberation on the pros and cons of the clinical trial was done.

RAC unanimously approved this clinical trial except abstention 1. Although approval of RAC is a big step, approval of the ethics committee of the institution to which the researcher belongs and approval of the US Food and Drug Administration (FDA) are also necessary, so clinical trials will be started right away It is not.

A Biotech company named Editas Medicine has already announced that clinical trials of CRISPR / Cas 9 will be conducted in 2017 to treat hereditary eye diseases, but this has already been approved by RAC I have not received it.