Scientists clarify why 'Runner' s High 'occurs that makes elegance feel good for running

ByBill Dickinson

Running, the mood gets elevated while runningRunners' HighAlthough it may become, scientists clarified why the physiological action that euphoria is obtained by running will occur.

Leptin Suppresses the Rewarding Effects of Running via STAT 3 Signaling in Dopamine Neurons: Cell Metabolism
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00394-0


"LeptinIs a substance produced in adipocytes and has a function related to the management of energy storage in the body and if you eat too much and unnecessary energy is ingested in the body, leptin is secreted, suppression of appetite, at the same time muscle It is a hormone that works like increasing energy consumption and preventing obesity. A research team at the University of Montreal who studied leptin also called "satiety hormone" found that runner's high is caused by lowering leptin levels.

Previous studies found that leptin levels fluctuate not only at the time of obesity but also by starvation / sleep deprivation / emotional stress. Furthermore, in this study, it was found that leptin in the body decreases during activities such as walking and running. When the leptin in the body decreases due to activities such as running, the famine signal is sent to the pleasure center of the brain, but it is said that the pleasure center is stimulated and runner's high is reached. It is regarded as an action to make it possible to search for food for a long time with a body of famine.

ByMarcovdz

Until now, although the mechanism of runner's high was not known in detail, a leptin-sensitive protein which releases dopamine and relays leptin "STAT 3"The research team who thought that it was influenced made a mouse deficient in STAT3 by genetic manipulation and conducted a comparative experiment with a normal mouse.

Normal mice, who became runner 's high due to a decline in leptin, ran an average of 6 kilometers of turning cars per day, but the genetically engineered mice ran an average of 11 km, which is nearly twice that of normal mice He said that. It was found that mice lacking STAT3 by genetic manipulation, that is, the muscles which became difficult to be affected by leptin, became more susceptible to runner 's high effect than usual mice. This means that as the leptin decreases, the effect of runner's high becomes greater.


"The result of the experiment is that not only the leptin level in the body greatly affects runner's high, but also the leptin level like a professional marathon player who is adjusting fat," said Stephanie Fulton, one of the researchers, The lower the person, the stronger the influence of runner's high by exercise, "Descriptiondoing.