It is confirmed that incorporation of young blood raises natural healing power

ByEvan Long

"Young blood rejuvenates the body of an old mouse"Research was published in 2014. In this research it was meant "There is a power to resurrect a cell aged in a protein in young blood", but another research team similarly found that if young blood is introduced into the body of an aged mouse, the natural healing power It turns out that it rises. In our study, it has been found that β-catenin is closely associated with rejuvenation.

Exposure to a youthful circulaton rejuvenates bone repair through modulation of [beta] -catenin: Nature Communications: Nature Publishing Group
http://www.nature.com/ncomms/2015/150519/ncomms8131/full/ncomms8131.html

This research was conducted at the University of TorontoToronto Children's HospitalWhat the team did. Responsibility of thesis Dr. Benjamin A. A. Arman is the orthopedic surgeon at Toronto Children's Hospital.

People who are older have lower natural healing power than younger people, slow recovery of injuries, slow bone repair at fracture, and titanium tooth integration with tooth implant treatmentOsseo IntegrationIt is late. However, I did not know why this bone repair rate, bone formation ability (ability to make bone) will change, why it is the cause.

As this trend is said to be the same for both humans and mice, when a team of Dr. Aluman and others investigated using a mouse,Young blood rejuvenated the old mouse bodyJust like in the study that "young blood is used, the natural healing power rises.

ByEddy Van 3000

In the experiment, the blood of two mice are joined in parallel so that they circulate to each other. One pair joined two non-young 20 month old mice (ISO below), and the other pair joined the 20 month old mouse and young mouse (HET below). Then HET got better than ISO, fractured bones and muscles recovered quickly.


Further experiments revealed that bone repair and osteoblast differentiation are accelerated in the same way by implanting young bone marrow even if it does not bind in parallel with young mice. Dr. Armand et al. Reported that the cause of this "rejuvenation"Wnt / β-catenin pathwayModulationI found out that there is. It also revealed the importance of playing a potential role in the inflammatory phase upon recovery from fracture and acting to cause an efficient inflammatory response.

It is hoped that in the future it will be possible to improve fracture restoration and osseointegration of the implant by reducing the function of the Wnt / β-catenin pathway and controlling the inflammatory response.