It is obvious that chronic sleep deprivation damages brain nerve
There are many people who are busy and living a life not having enough sleep time to eliminate lack of sleep by plenty of sleep on holidays.Penn MedicineAccording to the study, it turned out that chronic sleep deprivation not only can not be resolved by "sleeping" but also irreversible damage to brain cells.
Penn Medicine Researchers Show How Lost Sleep Leads to Lost Neurons
Many people know that sleep deprivation causes concentration or cognitive decline, but sleep deprivation inevitably can not be avoided depending on the type of duty. The common solution that people who are prone to sleep due to shift work commonly do not "sleep" at the weekend. HoweverThe Journal of NeuroscienceAccording to Penn Medicine's research published in Penn Medicine, it was revealed that chronic sleep deprivation contains more serious problems than previously thought and damages the brain cells unexpectedly .
"Even though cognitive decline generally decreases due to sleep deprivation, it is thought to be fully enjoyable by taking plenty of sleep at weekends etc, but according to multiple studies, the brain that was hurt by insufficient sleep was 3 days Even substitute sleep does not restore concentration or cognitive ability to the standard level, "he said.Sigrit BeigeeDr. is speaking. Experiments on sleep deprivation using a mouse have proved that neurons are damaged / lost by continuation of the awake state for a long period of time and proved to have an influence on cognitive ability.
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When we modeled the shift worker's normal / short sleep deprivation / chronic sleep deprivation pattern model and observed it with a mouse,CryocerebellarTurned out to regulate SirT3, which plays an important role in protecting neurons from mitochondrial energy production, redox reactions and metabolism. SirT3 is essential for maintaining anabolic homeostasis in short-term sleep deprivation, but SirT3 response is not seen in chronic sleep deprivation.
Observing the sleep patterns of shift workers for several days, the locus of the locus coeruleus in the mouse began to show shrinkage of SirT3, the percentage of cell death increased to 25%. "This is the first study that we found that neurons are damaged by sleep deprivation," said Dr. Bizy. In the future, we will verify whether similar decreases will occur in humans, and will focus on SirT 3 and conduct experiments. "If we can protect neurons from insomnia damage, we can set up a treatment policy for millions of shift workers," he said.
In addition, mouse experiments have proved that lack of sleep not only affects the locus of locus coerulea but also potentially accelerates neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Since both are reactions of mice at this stage, we are planning to autopsy the shifts workers who died to prove that they are affecting neurodegenerative diseases at the laboratory.
in Science, Posted by darkhorse_log