Sep 15, 2023 06:00:00

How is the new coronavirus vaccine, which the US Centers for Disease Control and Prevention recommended ``additional vaccination for everyone'', different from previous vaccines?

On September 12, 2023,

the Centers for Disease Control and Prevention (CDC) is recommending that all people six months of age and older receive a booster vaccine against the novel coronavirus disease (COVID-19). Prakash Nagarkatti of the University of South Carolina and others explain the differences between previous vaccines and the vaccine recommended by the CDC this time.

CDC greenlights two updated COVID-19 vaccines, but how will they fare against the latest variants? 5 questions answered
https://theconversation.com/cdc-greenlights-two-updated-covid-19-vaccines-but-how-will-they-fare-against-the-latest-variants-5-questions-answered-213341

The first vaccines against COVID-19 were shipped in December 2020. The vaccine at that time was designed as a 'monovalent vaccine' and was only effective against

SARS coronavirus 2 (SARS-CoV-2) at the early stage of its spread. As the body developed, the vaccine became less effective.

Therefore, in 2022, we plan to develop a 'bivalent' vaccine that targets both the original SARS-CoV-2 and new COVID-19 strains such as BA.4 and BA.5 from Omicron strains that were prevalent at the time. is now taking place.

However, SARS-CoV-2 continues to mutate, and in June 2023,

the U.S. Food and Drug Administration (FDA) requested vaccine developers to develop a vaccine against the continuing epidemic of ' XBB.1.5 '. .

The developed vaccine against XBB.1.5 will then be approved by the FDA, and vaccination will begin in the United States from fall 2023.

``Everyone except babies should be vaccinated against coronavirus in the fall of 2023,'' the Centers for Disease Control and Prevention recommends - GIGAZINE

On the other hand, according to Nagarkatti et al., the prevalence of XBB.1.5 in the United States has been replaced by EG.5 , FL.1.5.1, and XBB.1.16.6, and the effectiveness of new vaccinations remains uncertain. There are concerns . Still, the CDC says, ``We hope that additional vaccination with the newly developed vaccine will reduce the likelihood of severe COVID-19 and hospitalization.''

Pharmaceutical companies Moderna and Pfizer have developed new mRNA vaccines against COVID-19 in response to the spread of EG.5 and FL.1.5.1. Moderna has reported that administration of the developed vaccine significantly increased antibodies against EG.5 and FL.1.5.1. In addition, we have published clinical trial data that showed an 8.7-fold increase in neutralizing antibodies against the latest variant, BA.2.86, after vaccination.

Similarly, Pfizer announced that vaccination produced more neutralizing antibodies against the XBB.1.5, BA.2.86 and EG.5.1 variants.

The CDC recommends that this COVID-19 vaccine be given to all people 6 months and older, regardless of whether they have been previously vaccinated, to be vaccinated in September or October in preparation for winter, when virus transmission peaks. We recommend that you receive.