``Transforming antibiotics'' inspired by tanks will be developed, will it be a countermeasure to super bugs that do not work

With the advent of antibiotics, mankind has succeeded in dramatically reducing the threat of infectious diseases. However, in recent years, '

super bugs ' that are resistant to antibiotics have appeared, and existing antibiotics are becoming less effective. Meanwhile, a research team at the Cold Spring Harbor Laboratory succeeded in developing a ``structure-changeable antibiotic''. If this modified antibiotic is put into practical use, it is expected to be an effective countermeasure against super bugs.

Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria | PNAS

New shape-shifting antibiotics could fight deadly infections | Cold Spring Harbor Laboratory

Antibiotics are substances that suppress the function of bacteria and cause death, and are used to treat diseases caused by bacteria. However, just as ``mutant strains of the new coronavirus that vaccines are difficult to work with'' have become a hot topic, some bacteria have acquired ``resistance to antibiotics'' by repeating mutations. . Bacteria that are resistant to antibiotics are called 'superbugs', and while superbugs continue to increase, the development of new antibiotics is slowing down.

As a result of the increase in super bugs, about 3 million people in the United States are infected with super bugs annually, and 35,000 people die annually . The impact of super bugs has become noticeable not only in the United States but all over the world, and the Ministry of Health, Labor and Welfare is also discussing measures against super bugs.

In order to combat superbugs, we need to reduce the amount of antibiotics used and develop new antibiotics that superbugs cannot cope with. However, the current situation is that the development of antibiotics is slowing down, such as the World Health Organization (WHO)

announcing a report in 2023 that concluded that ``there is already no specific drug against superbugs.''

Meanwhile, a research team at the Cold Spring Harbor Laboratory announced that it had developed an antibiotic that could change its structure. According to Professor John E. Moses , a member of the research team, the idea of development came to mind when he visited military training and saw a ``tank equipped with a rotating turret''. The research team realized a ``structure-changeable antibiotic'' by combining the molecule `` Bullvalen '', which can change its structure in many ways, with the existing antibiotic ``vancomycin''.

As a result of administering a newly developed antibiotic to moths (moths) infected with `` vancomycin-resistant enterococci (VRE) '' that are resistant to vancomycin, it was confirmed that the bacteria removal effect was greater than when vancomycin was administered. it was done. Furthermore, it was not confirmed that VRE develops resistance to antibiotics. Professor Moses says that the technique of changing the structure of antibiotics could be used to develop a number of new drugs.

in Science, Posted by log1o_hf