Sep 06, 2022 07:00:00

It turns out that the risk of developing a stroke at a relatively young age differs depending on the 'blood type'

Stroke , in which blood vessels in the brain are clogged or ruptured, is a disease that affects people all over the world, and various studies on stroke risk have been conducted so far . A new study showed that 'people with type A blood are at a higher risk of developing a stroke while they are relatively young under the age of 60.'

Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke | Neurology
https://doi.org/10.1212/WNL.0000000000201006

Your blood type could predict your risk of h | EurekAlert!
https://www.eurekalert.org/news-releases/963353

Your Blood Type Affects Your Risk of an Early Stroke, Scientists Find : ScienceAlert
https://www.sciencealert.com/your-blood-type-affects-your-risk-of-an-early-stroke-scientists-find

Blood type is a method of classifying blood using differences in antigens on the surface of blood cells and antibodies contained in serum, and the most well-known are four types: A, B, O, and AB. It is ' ABO blood type ' classified into one. Blood grouping is also important medically because transfusion of a patient with one blood type with a different type of blood can result in serious side effects due to the combination of antigens and antibodies in the immune system.

In recent years, it has become clear that blood type is related to the severity of various diseases. For example, it is known that ``type B people are resistant to mainstream norovirus strains,'' and ``type O people have a low infection rate and severe rate of new coronavirus infection (COVID-19). , AB type is at high risk” has also been reported.

New study analyzes blood type and stroke risk using data from 16,730 stroke patients and 599,237 non-stroke patients from 48 different genetic studies . In this study, we used

genome-wide association analysis , which analyzes the relationship between the entire genome and disease, to investigate the relationship between ``early onset stroke (EOS)'' and blood type in people aged 18 to 59. thing.

As a result of the analysis, the research team reports that one of the two genetic regions strongly associated with the risk of early-onset stroke matched the gene that determines blood type. They also found that patients with early-onset stroke were more likely to have type A blood and less likely to have type O blood. Even after adjusting for gender and other risk factors, people with type A had a 16% higher risk of stroke than those with other blood types, and those with type O had a 12% lower risk. .

Furthermore, when the data of stroke patients and non-stroke patients aged 60 years and older were analyzed together, the increased risk of stroke in type A people was minimal in 'late onset stroke (LOS)' aged 60 years and older. It turns out. These results suggest that there may be different onset mechanisms between early-onset stroke occurring in people under the age of 59 and late-onset stroke in people over the age of 60. In this regard, the research team points out that arterial fat accumulation is less likely to cause stroke in young people, and instead factors related to thrombus formation are more likely to trigger stroke.

People with type B blood had an 11% higher risk of stroke regardless of age.

The research team argued that because the increase in stroke risk by blood type is small, type A does not require additional screening tests or special precautions. Co-senior author Steven J. Kittner, M.D., of the University of Maryland School of Medicine, said: 'While it is not yet clear why type A is associated with an increased risk of early-onset stroke, it is associated with the formation of blood clots. Blood clotting factors, such as platelets and vascular cells, and circulating proteins are likely involved.Further follow-up is needed to clarify the mechanisms that increase stroke risk. is clear,' he said.

In addition, this research data was collected from people living in North America, Europe, Japan, Pakistan, and Australia, and the proportion of non-European people was 35%. Therefore, Science Alert, a scientific media, argued that conducting studies using samples based on more diverse demographics would further clarify the importance of the results.