Research results that identified a gene that doubles the risk of death from the new corona
A research team at Oxford University in the United Kingdom has announced that it has identified 'a gene that can double the risk of death from a new coronavirus infection (COVID-19).'
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus | Nature Genetics
Scientists Find Gene That Doubles Risk of Dying From Covid-19 --Bloomberg
https://www.bloomberg.com/news/articles/2021-11-04/scientists-find-gene-that-doubles-risk-of-dying-from-covid-19
Study into gene that affects Covid severity should be treated with caution | Genetics | The Guardian
https://www.theguardian.com/science/2021/nov/04/human-genetic-variant-can-affect-covid-severity-say-oxford-scientists
According to the announcement, it is a gene called 'LZTFL1' that has the potential to double the risk of death for COVID-19. The mechanism of action of LZTFL1 has not been completely elucidated, but according to the research team, protection against a decrease in the viral receptor 'ACE2' on the surface of epithelial cells that line the lungs and respiratory tract during infection with the new coronavirus. There is a mechanism, and while this defense function works normally when LZTFL1 is a low-risk type, it is highly likely that it will not function because it is hindered by some factor when LZTFL1 is a high-risk type.
High-risk LZTFL1 is present in 60% of people of South Asian ancestry, 15% of whites of European ancestry, and only a few of African and Caribbean blacks. Only 2% said, the research team said, 'It could be a clue to explain the prevalence of infections in some racial groups and South Asia. However, during the first wave of infection, blacks were infected. He mentioned that there were many points in particular, and he declined that factors such as occupation, underlying disease, and place of residence also have a large effect, and that genes alone cannot influence the infection rate.
The researchers argue that vaccination is particularly effective for high-risk people, saying that 'LZTFL1 is a factor involved in the' infection 'of the new coronavirus and has nothing to do with the immune system.' 'If you think of a high-risk person getting very sick with Covid, it's 50% likely that he wouldn't have done that if he was a low-risk person,' he said. ..
On the other hand, the British letter, The Guardian, said, 'Even considering socio-economic factors, the risk of infection from people from India, Bangladesh and Pakistan in the UK is 50% higher, and the cause of this disparity is The explanation that it is in the gene seems plausible, 'he added, pointing out that 85% of the genetic data for each race used in this study is of European descent. He said it would be desirable to use a more racially unbiased database to draw valid conclusions.
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