New evidence of 'gut bacteria' associated with depression



Science, a major academic journal, reported the latest research results on 'intestinal bacteria that appear to be associated with depression.'

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort | Nature Genetics

https://www.nature.com/articles/s41588-021-00991-z

Gut microbe linked to depression in large health study | Science | AAAS
https://www.science.org/content/article/gut-microbe-linked-depression-large-health-study

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234057/

It is known that the brain and intestine are closely linked via humoral factors such as hormones and cytokines and the autonomic nervous system, and there is also the term gut -brain axis, which refers to the relationship between the brain and intestine. In recent studies, it is thought that the intestinal flora (intestinal flora), which refers to the innumerable bacteria that inhabit the intestine, is related to the intestine and the brain, so it is called 'brain-intestinal-intestinal bacterial correlation'. The term has even appeared, and research institutes around the world are conducting research on the brain-intestinal-gut microbiota correlation.

Gut-brain axis ③: Can't we talk about gut-brain axis without intestinal bacteria? !! | Special Content | Yakult Central Labo
https://institute.yakult.co.jp/feature/008/02.php



The new study, published by Guillaume Merrick of the Baker Institute in Australia and Michael Inouye of the University of Cambridge, UK, focuses on the relationship between genes and the gut microbiota. Using the 2002 data from the Finnish Institute for Health and Welfare's national health survey FINRISK , which has been conducted for about 40 years at a pace of once every five years, Merrick et al. Used the genetic composition and gut bacteria of 5959 subjects. I investigated the relationship of the plexus.

The theme of this analysis is 'Which genetic mutation affects the abundance of which gut bacteria', and each analysis result shows the relationship between the mutation status of the LCT gene involved in lactose resistance and the abundance of bifidobacteria. There were various things such as the relationship between the mutation status of the MED13L gene locus, which is suspected to be related to colorectal cancer, and the abundance of enterococcus faecalis . It is an intestinal microorganism that seems to be.

According to Merrick et al., Morganella bacteria were significantly increased in 181 people who later developed depression. In a 2008 study of Morgan bacteria, the results of a study that 'depressed patients show a strong immune response to chemicals produced by Morgan bacteria and other Gram-negative bacteria ' have been announced, and depression has been reported for many years. Has been suspected to be related. Therefore, this study, which cuts into the relationship between Morgan bacteria and depression from the field of genes, could be new evidence to prove that inflammation caused by gut microbiota affects mood. increase.



According to Gerald Clark, who studies the intestinal flora at the University of Cork in Ireland, research on the relationship between the intestinal flora and the brain is still in its infancy, and research on depression itself, which has various forms, is still in its infancy. And there are many issues regarding how the intestinal flora actually affects depression. Regarding the results of this survey, there is no clear idea of how to remove Morgan bacteria from the intestine, and it is said that the appearance of supplements that control the intestinal flora and lead to improvement of depression is 'a little more difficult'. That is.

in Science, Posted by log1k_iy